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Engulfment of Protruding Micro-Nails Fabricated on Chip Surface by Cultured Neurons Improve Their Adhesion to The Electronic Device

Published online by Cambridge University Press:  01 February 2011

Micha E. Spira ,
Dotan Kamber ,
Ada Dormann ,
Ariel Cohen ,
Carmen Bartic ,
Gustaaf Borghs ,
Keren Shabthai ,
J.P.M. Langedijk Langedijk ,
Shlomo Yitzchaik  and
Josef. Shappir
Micha E. Spira
Affiliation:
[email protected], The Hebrew University of Jerusalem, Life Sciences Inst. Neurobiology, Campus Edmond Safra, Jerusalem, 91904, Israel, 972-2-6585091, 972-2-5637033
Dotan Kamber
Affiliation:
[email protected], The Hebrew University of Jerusalem, Neurobiology, Jerusalem, 91904, Israel
Ada Dormann
Affiliation:
[email protected], The Hebrew University of Jerusalem, Neurobiology, Jerusalem, 91904, Israel
Ariel Cohen
Affiliation:
[email protected], The Hebrew University of Jerusalem, Neurobiology, Jerusalem, 91904, Israel
Carmen Bartic
Affiliation:
[email protected], IMEC, Cell Based Sensors & Circuits, Leuven, B-3001, Belgium
Gustaaf Borghs
Affiliation:
[email protected], IMEC, Cell Based Sensors & Circuits, Leuven, B-3001, Belgium
Keren Shabthai
Affiliation:
[email protected], The Hebrew University of Jerusalem, Inorganic and Analytical Chemistry, Jerusalem, 91904, Israel
J.P.M. Langedijk Langedijk
Affiliation:
[email protected], Pepscan, Lelystad, 2098, Netherlands
Shlomo Yitzchaik
Affiliation:
[email protected], The Hebrew University of Jerusalem, Inorganic and Analytical Chemistry, Jerusalem, 91904, Israel
Josef. Shappir
Affiliation:
[email protected], The Hebrew University of Jerusalem, School of Engineering, Jerusalem, 91904, Israel
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Abstract

One of the major problems in assembling efficient neuro-electronic hybrids systems is the low electrical coupling between the components. This is mainly due to the low resistance, extracellular cleft formed between the cell's plasma membrane and the substrate to which it adhere. This cleft shunts the current generated by the neuron, or the device and thus reduces the signal to noise ratio. To increase the clefts electrical resistance we fabricated gold micronails that protrude from the transistor gate surface. The micronails were functionalized by phagocytosis facilitating peptides. Cultured neurons readily engulf the functionalized micronails forming tight physical contact between the cells and the surface of the device

Keywords

biologicalsensoradhesion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1004: Symposium P – Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Microfactories, and Fluidic Assembly of Nanostructures , 2007 , 1004-P02-05
Copyright
Copyright © Materials Research Society 2007

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References

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