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Engineered Films of Bombyx mori Silk with Poly(ethylene oxide)

Published online by Cambridge University Press:  11 February 2011

Hyoung-Joon Jin ,
Jaehyung Park ,
Peggy Cebe  and
David L. Kaplan
Hyoung-Joon Jin
Affiliation:
Department of Chemical & Biological Engineering, Bioengineering Center, Medford, MA 02155, U.S.A.
Jaehyung Park
Affiliation:
Department of Chemical & Biological Engineering, Bioengineering Center, Medford, MA 02155, U.S.A.
Peggy Cebe
Affiliation:
Department of Physics and Astronomy, Tufts University, 4 Colby Street, Medford, MA 02155, U.S.A.
David L. Kaplan
Affiliation:
Department of Chemical & Biological Engineering, Bioengineering Center, Medford, MA 02155, U.S.A.
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Abstract

Phase separation into controllable patterned microstructures was observed for Bombyx mori silkworm silk and poly(ethylene oxide) (PEO) (900,000 g/mol) blends cast from aqueous solution. Solution blending was used to incorporate water-soluble PEO into silk to enhance elasticity and hydrophilicity. The sizes of the globule fibroin phase ranged from 3.1±0.9 μm to 18.2±2.1 μm depending on the ratio of silk/PEO. Optical microscopy and SEM analysis confirmed the micro-phase separation between PEO and silk. Surface properties were determined by contact angle. The PEO can be easily extracted from the films with water to generate silk matrices with definable porosity and enhanced surface roughness. These blend films formed from two biocompatible polymers provide new potential tissue engineering scaffolds and controlled release drug delivery materials.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 735: Symposium C – Bioinspired Nanoscale Hybrid Systems , 2002 , C11.11
Copyright
Copyright © Materials Research Society 2003

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References

REFERENCES

1. Sofia, S., McCarthy, M. B., Gronowicz, G., and Kaplan, D. L., Journal of Biomedical Materials Research 54, 139 (2001).Google Scholar
2. Shao, Z. and Vollrath, F., Nature 418, 741 (2002).Google Scholar
3. Altman, G. H., Horan, R. L., Lu, H. H., Moreau, J., Martin, L., Richmond, J. C., and Kaplan, D. L., Biomaterials 23, 4131 (2002).Google Scholar
4. Alcantar, N. A., Aydil, E. S., and Israelachvili, J. N., Journal of Biomedical Materials Research 51, 343 (2000).Google Scholar
5. Desai, N. P., and Hubbell, J. A., Biomaterials 12, 144 (1991).Google Scholar
6. Jin, H.-J., Fridrikh, S. V., Rutledge, G. C., and Kaplan, D. L., Biomacromolecules 3, 1233 (2002).Google Scholar