Paradigmatically, the convergence of science has exceptionally high potential for transforming the manner in which state-of-the-art information is gathered, analyzed, and leveraged to enable future advances and applications. Highlighting the potential and challenges of hierarchically integrating nanotechnologies is essential for realizing commercial applications. The heterogeneity of structures and compositions of nanomaterials present limitless possibilities; yet these envisioned benefits may be accompanied by certain technological limitations of integrating nanomaterials in commercial products. A balanced overview is presented of the realistic capabilities and potential, as well as the limitations, challenges of system engineering nanomaterials in platform integration. Examples of integrating nanomaterials in useable platforms are also presented. Most notably, the review suggests that nanomaterial based systems and devices that do not require a nano to micro/macro interface integration have reached commercialization whereas those needing a nano-to-micro/macro interface require further investigations. These selected studies provide an insight in obstacles and challenges presented by hierarchical integration of nanomaterials in commercial systems/devices and are crucial for commercialization as the research transitions from laboratory to marketplace, having the potential to transform into a multi-billion dollar niche market.