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Published online by Cambridge University Press: 01 February 2011
Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans are considered key pathogens in periodontitis that is the principal cause of tooth loss in adults. The treatment of periodontal disease consists on the use of chemicals which can alter oral microbiota and have undesirable side-effects such as vomiting, diarrhea and tooth staining
At recent years, the use of natural sources like biomaterials such as biopolymers and plant extracts are enjoying great popularity. Chitosan and pullulan are polymers that have been proposed due to their favorable properties such as biocompatibility, biodegradability, adhesion ability and nontoxicity
The aim of this study was to develop films from chitosan and pullulan containing plant extracts as delivery system and determine the in vitro antibacterial activity against periodontopathogen microorganisms and their stability under different conditions of storage