Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T01:51:07.823Z Has data issue: false hasContentIssue false
  • English
  • Français

Efficient Upconverting Nanophosphors for Imaging and Photodynamic Therapy

Published online by Cambridge University Press:  11 July 2012

Brian G. Yust ,
Gangadharan Ajith Kumar ,
Lawrence C. Mimun  and
Dhiraj K. Sardar
Brian G. Yust
Affiliation:
Dept. of Physics & Astronomy, Univ. of Texas at San Antonio, One UTSA Circle, San Antonio, Tx, 78249-1644 U.S.A.
Gangadharan Ajith Kumar
Affiliation:
Dept. of Physics & Astronomy, Univ. of Texas at San Antonio, One UTSA Circle, San Antonio, Tx, 78249-1644 U.S.A.
Lawrence C. Mimun
Affiliation:
Dept. of Physics & Astronomy, Univ. of Texas at San Antonio, One UTSA Circle, San Antonio, Tx, 78249-1644 U.S.A.
Dhiraj K. Sardar
Affiliation:
Dept. of Physics & Astronomy, Univ. of Texas at San Antonio, One UTSA Circle, San Antonio, Tx, 78249-1644 U.S.A.
Get access

Abstract

Erbium-Ytterbium codoped nanophosphor systems are explored for high efficiency upconversion. The NIR to visible upconversion from 1550 nm and 980 nm excitation are of particular interest to us for biomedical applications such as imaging, sensing, and photodynamic therapy. Variations in synthesis method and rare earth concentration are carried out in sodium, potassium, and transition metal based phosphor materials. The spectroscopic properties of the material dry and in biologically appropriate solution are taken. After bioconjugation, these particles will be used in a mouse model to demonstrate that cancer imaging with a near-infrared excitation source is possible.

Keywords

nanostructureluminescencelanthanide
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1471: Symposium YY – Rare-Earth-Based Materials , 2012 , mrss12-1471-yy07-06
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Ye, X., Collins, J.E., et al. ., “Morphologically controlled synthesis of colloidal upconversion nanophosphors and their shape-directed self-assembly”, Proc. of the National Academy of Sciences, vol. 107, no. 52, pp. 22430–22435 (2010).10.1073/pnas.1008958107Google Scholar
2. Mai, H.X., Zhang, Y.W., et al. ., “High-Quality Sodium Rare-Earth Fluoride Nanocrystals:Controlled Synthesis and Optical Properties”, Journal of the American Chemical Society, vol. 128, no. 19, pp 6427–6436 (2006).10.1021/ja060212hGoogle Scholar
3. Wang, M., Mi, C.C., et al. ., “One-step synthesis and characterization of water-soluble NaYF4:Yb, Er/Polymer nanoparticles with efficient up-conversion fluorescence”, Journal of Alloys and Compounds, vol. 485, pp L24–L27 (2009).Google Scholar
4. Xiong, L., Yang, T., et al. ., “Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors”, Biomaterials, vol. 31, pp 7078–7085 (2010).10.1016/j.biomaterials.2010.05.065Google Scholar
5. Wang, J., Wang, F., et al. ., “Single-Band Upconversion Emission in Lanthanide-Doped KMnF3 Nanocrystals”, Angew. Chem. Int. Ed.s, vol. 50, pp 10369–10372 (2011).10.1002/anie.201104192Google Scholar