Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-25T15:25:59.107Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of Metal Ions on Apatite Formation and Bone Mineralization

Published online by Cambridge University Press:  15 February 2011

N. C. Blumenthal  and
V. Cosma
N. C. Blumenthal
Affiliation:
Department of BioengineeringHospital for Joint Diseases Orthopaedic Institute301 East 17th StreetNew York, NY 10003
V. Cosma
Affiliation:
Department of BioengineeringHospital for Joint Diseases Orthopaedic Institute301 East 17th StreetNew York, NY 10003
Get access

Extract

Certain metals (such as Al) are known to cause bone pathologies in humans and animals. While little is known about the mechanism of action of metals on either the formation of bone or on the physical-chemical properties of the mineral phase, there is considerable evidence that (1) Al and Cd directly affect the formation and properties of HA and thus are a causative factor in metal-related defective bone formation—in addition to any cellular effects which they may induce; (2) that other transition metals (such as Cr, V, Ti, Ni, Co), which are used in joint prostheses, significantly affect HA formation; and (3) gallium, the most effective antihypercalcemic agent, affects apatite formation and solubility.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 29
Copyright
Copyright © Materials Research Society 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Verbueken, A H, Van de Vyver, F L,Van Greiken, R E, Paulus, G J, Visser, W J, D'Haese, P D, DeBroe, M E: Ultrastructural localization of aluminum in patients with dialysis-associated osteomalacia. Clin Chem 30:763, 1984.Google Scholar
2. Plachot, J, Cournot-Witner, G, Halpem, S, Mendes, V, Bordeau, A, Fritsch, J, Bourdon, R, Drueke, T, Galle, P, Balson, S: Bone ultrastructure and x-ray microanalysis of aluminum-intoxicated hemodialyzed patients. Kidney Int 25:796, 1984.CrossRefGoogle ScholarPubMed
3. Brown, D J, Dawborn, J K, Ham, K M, Xipell, J M: Treatment of dialysis osteomalacia with desferrioxamine. Lancet 2:343, 1982.Google Scholar
4. Chan, Y L, Alfrey, A C, Posner, S, Lissner, D, Hille, E, Dunstan, C R, Evans, R A: Effect of aluminum on normal and uremic rats: tissue distribution, vitamin D metabolites, and quantitative bone histology. Calc Tiss Int 35:344, 1983.CrossRefGoogle ScholarPubMed
5. Beder, O E, Eade, G: An investigation of tissue tolerance to titanium metal implants in dogs. Surgery 39:470, 1956.Google Scholar
6. Warrell, R P Jr, Bockman, R S, Coonley, S J, Isaacs, M, Staszcwski, H: Gallium nitrate inhibits calcium resorption from bone and is effective treatment for cancer-related hypercalcemia. J Clin Invest. 73:1487, 1984.Google Scholar
7. Blumenthal, N. C., and Posner, A. S.: Surface poisoning of synthetic and biological apatites. Colloids and Surfaces 26:123, 1987.Google Scholar
8. Blumenthal, N. C., Posner, A. S., and Holmes, J. M.: Effect of preparation conditions on the properties and transformation of amorphous calcium phosphate. Mat. Res. Bull. 7:1181, 1972.CrossRefGoogle Scholar
9. Betts, F., and Posner, A. S.: A structural model for amorphous calcium phosphate. Trans Am. Cryst. Assoc. 10:73, 1974.Google Scholar
10. Blumenthal, N. C., Betts, F., and Posner, A. S.: Stabilization of amorphous calcium phosphate by Mg and ATP. Calcif. Tiss. Res. 23:245, 1977.Google Scholar
11. Landis., W. J., and Glimcher, M. J.: Electron diffraction and electron probe microanalysis of the mineral phase of bone tissue prepared by anhydrous techniques. J. Ultrastruct. Res. 63:188, 1978.Google Scholar
12. Boskey, A. L., and Posner, A. S.: Formation of hyroxyapatite at low supersaturation. J. Phys. Chem. 80:40, 1976.Google Scholar
13. Betts, F., Blumenthal, N. C. Posner, A. S. Becker, G. L., and Lehninger, A. L.: Atomic structure of intracellular amorphous calcium deposits. Proc. Nat. Acad. Sci. 72:2088, 1975.Google Scholar
14. Blumenthal, N. C., Betts, F., and Posner, A. S.: Effect of carbonate and biological macromolecules on formation and properties of hydroxyapatite. Calcif. Tiss. Res. 18:81, 1975.Google Scholar
15. Boskey, A. L. and Posner, A. S.: Magnesium stabilization of amorphous calcium phosphate: a kinetic study. Mat. Res. Bull. 9:907, 1974.Google Scholar
16. Amjad, Z., Koutsoukos, , and Nancollas, G. H.: The crystallization of hydroxyapatite and fluorapatite in the presence of magnesium ions. J. Coll. Int. Sci. 101(1):250, 1984.Google Scholar
17. McGann, T-C. A., Kearney, R. D., Buchheim, W., Posner, A. S., Betts, F., and Blumenthal, N. C.: Amorphous calcium phosphate in casein micelles of bovine milk. Calcif. Tiss. Int. 35:821, 1983.Google Scholar
18. Posner, A. S., Blumenthal, N. C., and Betts, F.: Chemistry and structure of precipitated hydroxyapaptites. In Friagu, J. O., and Moore, P. B. (eds.): Phosphate Minerals. New York, Springer-Verlag, 1984, p. 330.Google Scholar
19. Lowenstam, H. A.: Phosphate hard tissues of marine invertebrates: their nature and mechanical function and some fossil implications. Chem. Geol. 9:153, 1972.Google Scholar
20. Blumenthal, N. C., and Posner, A. S.: In vitro model of aluminum-induced ostomalacia: inhibition of hydroxyapatite formation and growth. Calc. Tiss. Int. 36:439, 1984.Google Scholar
21. Posner, A. S., Blumenthal, N. C., and Boskey, A. L.: Model of aluminum-induced osteomalacia: inhibition of hydroxyapatite formation and growth. Kidney Int. 29 Suppl. 18:17, 1986.Google Scholar
22. Blumenthal, N. C.: Binding of aluminum to hydroxyapatite and amorphous calcium phosphate as a model for aluminum-associated osteomalacia. In Butler, W. T. (ed.): The Chemistry and Biology of Mineralized Tissues. Birmingham, Ala., EBSCO Media, 1985, p. 385.Google Scholar
23. Blumenthal, N. C., Cosma, V., and Levine, S. Effect of gallium on the in vitro formation, growth, and solubility of hydroxyapatite. Calcified Tissue International, 45, 81–87, 1989.Google Scholar
24. Blumenthal, N. C., and Cosma, V. Inhibition of apatite formation by titanium and vanadium ions. Journal of Biomedical Materials Research: Applied Biomaterials, 23(1), 13, 1989.CrossRefGoogle ScholarPubMed