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Effect of Ligand Density Gradient on the Adhesion Kinetics of Biological Membranes

Published online by Cambridge University Press:  01 February 2011

Alireza Sarvestani  and
Esmaiel Jabbari
Alireza Sarvestani
Affiliation:
[email protected], University of South Carolina, Department of Chemical Engineering, 301 South Main St., Columbia, SC, 29208, United States, 8037777398
Esmaiel Jabbari
Affiliation:
[email protected], University of South Carolina, Department of Chemical Engineering, 301 South Main St., Columbia, SC, 29208, United States
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Abstract

An analytical model is developed for the effect of surface gradient in ligand density on the adhesion kinetics of a curved elastic membrane with mobile receptors. The displacement and speed of spreading at the edge of the adhesion zone as well as the density profile of receptors along the membrane are predicted as a function of time. According to results, in the diffusion-controlled regime, the front edge displacement of adhesion zone and the rate of membrane spreading decreased with increasing ligand density in a certain direction. Furthermore, the displacement of the edge of the adhesion zone did not scale with the square root of time, as observed on substrates with uniform ligand density.

Keywords

adhesionbiologicaldiffusion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1063: Symposium OO – Solids at the Biological Interface , 2007 , 1063-OO01-10
Copyright
Copyright © Materials Research Society 2008

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References

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