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Early Nucleation Events in the Biomineralization of Calcium Phosphates

Published online by Cambridge University Press:  09 February 2011

Baoquan Xie  and
George Nancollas
Baoquan Xie
Affiliation:
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, U.S.A.
George Nancollas
Affiliation:
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, U.S.A.
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Abstract

Our work focuses on the earliest events of homo-/heterogeneous nucleation from an initial supersaturated solution to the subsequent growth of nuclei. The combined use of conductance, together with hydrogen and calcium ISEs has provided new insights into the mechanisms of crystal nucleation and phase stability. We propose that two types of ACP are formed during HAP nucleation. The initial subcritical calcium-phosphate ion clusters form an amorphous [CaHPO4·xH2O] phase (ACP-1), which transforms to amorphous [Ca3(PO4)2] (ACP-2), and subsequently to HAP. This study is a major step forward in our understanding of the earliest nucleation events in vitro and in vivo. Additives may influence HAP nucleation by interacting with ACP clusters during the early induction period.

Keywords

nucleation & growthbiomaterialcrystal growth
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1301: Symposium V/NN/OO/PP – Soft Matter, Biological Materials and Biomedical Materials—Synthesis, Characterization and Applications , 2011 , mrsf10-1301-nn01-01
Copyright
Copyright © Materials Research Society 2011

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References

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