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Dual Functionalized Janus Nanocomposites for Targeted pH-Responsive Drug Delivery

Published online by Cambridge University Press:  17 February 2014

Feng Wang ,
Giovanni Pauletti ,
Yilong Wang  and
Donglu Shi
Feng Wang
Affiliation:
The Materials Science and Engineering Program, University of Cincinnati, Cincinnati, OH 45221(USA),
Giovanni Pauletti
Affiliation:
James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267 (USA),
Yilong Wang
Affiliation:
The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai, 200092, China.
Donglu Shi*
Affiliation:
The Materials Science and Engineering Program, University of Cincinnati, Cincinnati, OH 45221(USA),
*
*Email: [email protected]
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Abstract

A superparamagnetic Janus nanocomposite (SJNC) of polystyrene/Fe3O4@SiO2 was designed and developed with dual surface bearing functional groups for medical diagnosis and treatment. Folic acid (FA) and doxorubicin (DOX) were conjugated stepwise to the surfaces. SJNCs were found to enable simultaneous cell-targeted drug delivery via pH-responsive release mechanism.

Keywords

nanostructurecompositesurface reaction
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1625: Symposium I – Multiscale Materials in the Study and Treatment of Cancer , 2014 , mrsf13-1625-i06-11
Copyright
Copyright © Materials Research Society 2014 

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References

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