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Development of Switchable “Smart” Biomaterials Using an Environmental Friendly Technology

Published online by Cambridge University Press:  31 January 2011

Telma Barroso ,
Raquel Viveiros ,
Eunice Costa ,
Márcio Temtem ,
Teresa Casimiro  and
Ana Aguiar-Ricardo
Telma Barroso
Affiliation:
[email protected], REQUIMTE, FCT, Universidade Nova de Lisboa, Dep. Química, Caparica, Portugal
Raquel Viveiros
Affiliation:
[email protected], REQUIMTE, FCT, Universidade Nova de Lisboa, Dep. Química, Caparica, Portugal
Eunice Costa
Affiliation:
[email protected], REQUIMTE, FCT, Universidade Nova de Lisboa, Dep. Química, Caparica, Portugal
Márcio Temtem
Affiliation:
[email protected], REQUIMTE, FCT, Universidade Nova de Lisboa, Dep. Química, Caparica, Portugal
Teresa Casimiro
Affiliation:
[email protected], REQUIMTE, FCT, Universidade Nova de Lisboa, Dep. Química, Caparica, Portugal
Ana Aguiar-Ricardo
Affiliation:
[email protected], REQUIMTE, FCT, Universidade Nova de Lisboa, Dep. Química, Caparica, Portugal
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Abstract

The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO2 environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli. In situ synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.

Keywords

polymerizationbiomaterialenvironmentally benign
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1220: Symposium BB – Green Chemistry in Research and Development of Advanced Materials , 2009 , 1220-BB01-07
Copyright
Copyright © Materials Research Society 2010

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References

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