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Development of Blood Compatible Alpha-lipoic acid Coated Stent with a Good Adhesive by Low Temperature Plasma Polymerization

Published online by Cambridge University Press:  15 March 2011

Sun-Jung Song ,
Kyoung Seok Kim ,
Dong Lyun Cho  and
Myung Ho Jeong
Sun-Jung Song
Affiliation:
Center for Functional Nano Fine Chemicals, 2nd stage of Brain Korea 21, Chonnam National University, Gwangju 500-757, Korea
Kyoung Seok Kim
Affiliation:
Center for Functional Nano Fine Chemicals, 2nd stage of Brain Korea 21, Chonnam National University, Gwangju 500-757, Korea
Dong Lyun Cho
Affiliation:
Center for Functional Nano Fine Chemicals, 2nd stage of Brain Korea 21, Chonnam National University, Gwangju 500-757, Korea
Myung Ho Jeong
Affiliation:
The Heart Center of Chonnam National University Hospital
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Abstract

Neointimal hyperplasia is a main cause for in-stent restenosis after stent-implantation and is triggered by inflammatory response to foreign materials. It can be inhibited if the stent is modified to have good blood compatibility by coating drug compounds. Low temperature plasma polymerization of 1, 2-diaminocyclohexane was performed to prepare more adhesive polymeric thin film onto the metallic stent. Then, the chemical grafting of α-lipoic acid (ALA) was carried out to improve blood compatibility of stent. Drugs containing carboxylic groups can be chemically grafted through the formation of amide bond in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide methiodide onto the DACH deposited stent surface. ALA grafted film showed good mechanical stability and blood compatibility.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1132: Symposium Z – Mechanics of Biological and Biomedical Materials , 2008 , 1132-Z08-01
Copyright
Copyright © Materials Research Society 2009

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References

REFERENCES

1. Sousa, J. E., Costa, M. A., Abizaid, A., Abizaid, A. S., Feres, F., Pinto, I. M., Seixas, A. C., Staico, R., Mattos, L. A., Sousa, A. G., Falotico, R., Jaeger, J., Popma, J. J. and Serruys, P. W., Circulation, 103, 192 (2001).Google Scholar
2. Perin, E. C., Rev. Cardiovasc. Med., 6 (suppl 1), 13 (2005).Google Scholar
3. Kamath, K. R., Barry, J. J. and Miller, K. M., Adv. Drug Deliv. Rev., 58(3), 412 (2006).Google Scholar
4. Rogers, C. D., Rev Cardiovasc Med., 5 (suppl 2), S9 (2004).Google Scholar
5. Virmani, R., Liistro, F. and Stankovic, G., Circulation, 106, 2649 (2002).Google Scholar
6. Lee, K.-M., Park, K.-G., Kim, Y.-D., Lee, H.-J., Kim, H. T., Cho, W.-H., Kim, H.-S., Han, S.-W., Koh, G. Y., Park, J.-Y., Lee, K.-U., Kim, J.-G. and Lee, I.-K., Atherosclerosis., 189, 106 (2006).Google Scholar
7. Lim, S.Y., Bae, E. H., Jeong, M. H., Kim, J. H., Ahn, Y. K., Cho, J. G., Park, J. C., Kang, J. C., Cho, D. L., Kim, K.-S. and Joo, S.-J., Kor. Circulation J., 36, 495 (2006).Google Scholar
8. Golander, C.-G., Rutland, M. W., Cho, D. L., Johansson, A., RingBlom, H., Jonsson, S. and Yasuda, H., J. Appl. Polym. Sci., 49, 39 (1993).Google Scholar
9. Jaegere, P. P. de, Feyter, P. J. de, Giessen, W. J. van der and Serruys, P. W., Clin. Cardiol., 16(5), 369 (1993).Google Scholar
10. Nurdin, N., Francois, P., Mugnier, Y., Krumeich, J., Moret, M., Anderson, B. O. and Descouts, P., Eur. Cell. Mater., 5, 17 (2003).Google Scholar