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Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

Published online by Cambridge University Press:  15 February 2011

Y.S. Chen ,
C. Miller ,
M.H. Greer ,
M. Quinones  and
R.T. Greer
Y.S. Chen
Affiliation:
Iowa State University, Biomedical Engineering ProgramAmes, IA 50011
C. Miller
Affiliation:
Iowa State University, Biomedical Engineering ProgramAmes, IA 50011
M.H. Greer
Affiliation:
Iowa State University, Biomedical Engineering ProgramAmes, IA 50011 Department of Biomedical SciencesAmes, IA 50011
M. Quinones
Affiliation:
Department of Veterinary Clinical Sciences, and Department of Aerospace Engineering and Engineering Mechanics, Ames, IA 50011
R.T. Greer
Affiliation:
Iowa State University, Biomedical Engineering ProgramAmes, IA 50011
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Abstract

Silicone rubber multiple-lumen (ML) nerve cuffs were used for side-by-side comparisons of the effectiveness of two varieties of nerve growth stimulants (collagen gel and a gel mixture of collagen, fibronectin, and laminin) for regenerating cables across a 15 mm gap in 10 adult Sprague-Dawley rats. The filling pattern of the six tubes of the multiple-lumen portion of the cuff alternated with the collagen gel and the gel mixture of collagen, fibronectin, and laminin. After an 8 week implantation period, 53% (32 of 60) of the 0.5 mm diameter lumens displayed successful cable regeneration for both material fillings. The ML cuff experiments demonstrate the ability to bridge a 15 mm gap in the sciatic nerve of the rat by 8 weeks for relatively small diameter conduits in ML cuffs loaded with two varieties of growth stimulants. A more advanced organization including a smaller acellular region fraction and a higher vascularity is seen in the cables from the mixture-filled lumens compared to those in the cables from the collagen-filled lumens.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 303
Copyright
Copyright © Materials Research Society 1999

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