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Decreased Macrophage Density on Carbon Nanofiber Patterns

Published online by Cambridge University Press:  01 February 2011

Jong Youl Kim ,
Dongwoo Khang ,
Jong Eun Lee  and
Thomas J. Webster
Jong Youl Kim
Affiliation:
Brown University, Engineering, 184 Hope Street, Providence, RI, 02917, United States, (401) 863-2318
Dongwoo Khang
Affiliation:
[email protected], Brown University, Engineering, 184 Hope Street, Providence, RI, 02912, United States
Jong Eun Lee
Affiliation:
[email protected], College of Medicine, Yonsei University, Anatomy, Seoul, 120-752, Korea, Republic of
Thomas J. Webster
Affiliation:
[email protected], Brown University, Engineering, 184 Hope Street, Providence, RI, 02912, United States
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Abstract

In this study, we describe the selective adhesion 4 hour and proliferation 24 hour and 4 days of inflammatory cells (specifically, macrophages) on aligned carbon nanofiber/nanotube patterns on a polymer matrix. The results showed for the first time that macrophage adhesion and proliferation on aligned Carbon nanofibers (CNFs) was significantly less than on the polymer matrix. The present in vitro study thus provided evidence of the ability of CNFs to down-regulate macrophage adhesion and proliferation important to decrease harmful body reaction, which is imperative for the future consideration of CNFs for numerous implant applications.

Keywords

nanoscaleCpolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D04-23
Copyright
Copyright © Materials Research Society 2007

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References

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