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The Cytotoxicity of Quantum Dots CdSe/CdS functionalized with -COOH and –NH2

Published online by Cambridge University Press:  31 January 2011

Lin-Jing Shen ,
Jing Cui ,
Jin-Hua Liu ,
Xiao-Bo Xu  and
Ming-Qiang Zhu
Lin-Jing Shen
Affiliation:
[email protected], Hunan University, Changsha, Hunan, China
Jing Cui
Affiliation:
[email protected], Hunan University, Changsha, Hunan, China
Jin-Hua Liu
Affiliation:
[email protected], Hunan University, Changsha, Hunan, China
Xiao-Bo Xu
Affiliation:
[email protected], Hunan University, Changsha, Hunan, China
Ming-Qiang Zhu
Affiliation:
[email protected], Hunan University, Changsha, China
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Abstract

Recently, semiconductor nanocrystals or quantum dots (QDs) aroused great concern because of their unique properties such as the size-dependent photoluminescence. They have many excellent applications in areas of molecular bioimaging, medical detection and even energy, especially as biosensing and imaging instead of fluorescent dyes. For the bio-safety, however, we should assess the cytotoxicity of QDs before used in biomedical imaging. Here, the cytotoxicity of amino-functionalized CdSe/CdS (CdSe/CdS-NH2) QDs and carboxy-functionalized CdSe/CdS (CdSe/CdS-COOH) QDs was investigated by MTT assay method. According to our findings, both CdSe/CdS-NH2 and CdSe/CdS-COOH have a dose-dependent effect on cell proliferation. The cytotoxicity of QDs varies with storing time of QDs and kinds of cells. The cytotoxicity of QDs modified with -COOH or -NH2 groups both vary with concentrations in positive linear or change with QD storing time in negative linear. The results indicate that CdSe/CdS-COOH QDs have lower toxicity than CdSe/CdS-NH2 QDs. Hela cell is somewhat more sensitive to amino- and carboxy-modified QDs than Bel7404 cell for MTT assays.

Keywords

biomedicalcolloidcore/shell
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1220: Symposium BB – Green Chemistry in Research and Development of Advanced Materials , 2009 , 1220-BB06-04
Copyright
Copyright © Materials Research Society 2010

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