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Customization of mechanical properties and porosity of bone tissue scaffold materials via Layer-by-Layer assembly of polymer-nanocomposite coatings

Published online by Cambridge University Press:  08 October 2015

M. Ziminska ,
N. Dunne  and
A. Hamilton
M. Ziminska
Affiliation:
School of Mechanical & Aerospace Engineering, Queen’s University Belfast, Northern Ireland
N. Dunne
Affiliation:
School of Mechanical & Aerospace Engineering, Queen’s University Belfast, Northern Ireland
A. Hamilton
Affiliation:
School of Mechanical & Aerospace Engineering, Queen’s University Belfast, Northern Ireland
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Abstract

The aim of this preliminary study was to adapt Layer-by-Layer (LbL) assembly to fabricate nanocomposite coatings onto open-cell porous structures, enabling customization of mechanical properties and porosity to obtain materials suitable for bone tissue scaffold applications. LbL assembly is a well-established method for fabricating multilayer films with nanometre scale precision over thickness that is based on electrostatic attractions and involves the adsorption of oppositely charged electrolytes onto a substrate. Using LbL assembly, polymer-nanoclay composite coatings were deposited onto open-cell foam substrates. The elastic modulus of coated specimens in compression was improved from 0.078 MPa to 1.736 MPa. The results suggest that polymer-nanoclay coatings deposited via LbL assembly have the potential to improve mechanical properties of porous substrates and fabricate materials with mechanical properties comparable to that of a cancellous bone tissue upon deposition of a sufficient number of multilayers.

Keywords

thin filmnanostructurelayered
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1793: Symposium GG – Foundations of Bio/Nano Interfaces―Synthesis, Modeling, Design Principles and Applications , 2015 , pp. 67 - 72
Copyright
Copyright © Materials Research Society 2015 

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References

REFERENCES

Tanner, K., Journal of Engineering in Medicine, 224, 1359–1371 (2010).CrossRefGoogle Scholar
Hutmacher, D., Schantz, J., Lam, C., Tan, K. C. and Lim, T., J. Tissue Eng. Regen. Med., 1, 245–260 (2007).CrossRefGoogle Scholar
Yoo, D., Shiratori, S. and Rubner, M., Macromolecules, 31, 4309–4318 (1998).CrossRefGoogle Scholar
Quinn, J. J. A., Such, G., Zelikin, A. and Caruso, F., Chem. Soc. Rev., 36, 707–718 (2007).CrossRefGoogle Scholar
Yang, Y.-H., Haile, M., Park, Y., Malek, F. and Grunlan, J., Macromolecules, 44, 1450–1459, (2011).CrossRefGoogle Scholar
Podsiadlo, P., Kaushik, A., Arruda, E., Waas, A., Shim, B., Xu, J., Nandivada, H., Lahann, P. B. J., Ramamoorthy, A. and Kotov, N., Science, 318, 80–83, (2007).CrossRefGoogle Scholar
Podsiadlo, P., Michel, M., Lee, J., Verploegen, E., Wong Shi Kam, N., Ball, V., Lee, J., Qi, Y., Hart, J., Hammond, P. and Kotov, N., Nano Letters, 8, 1762–1770, (2008).CrossRefGoogle Scholar
Patel, P., Shepherd, D. and Hukins, D., BMC Musculoskeletal Disorders, 9, 137–144, (2008).CrossRefGoogle Scholar
Szivek, J., Thomas, M. and Benjamin, J., J. Appl. Biomater., 4, 269–272, (1993).CrossRefGoogle Scholar
Li, Y.-C., Kim, Y., Shields, J. and Davis, R., J. Mater. Chem. A, 1, 12987–12997, (2013).CrossRefGoogle Scholar
Kim, Y., Harris, R. and Davis, R., ACS Macro Letters, 1, 820–824, (2012).CrossRefGoogle Scholar