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Creation of Novel Nano-Bio Conjugates for Life Sciences Using Gas-Liquid Phases Plasmas

Published online by Cambridge University Press:  21 May 2012

Toshiro Kaneko  and
Rikizo Hatakeyama
Toshiro Kaneko
Affiliation:
Department of Electronic Engineering, Tohoku University, Sendai 980-8579, Japan
Rikizo Hatakeyama
Affiliation:
Department of Electronic Engineering, Tohoku University, Sendai 980-8579, Japan
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Abstract

The gold nanoparticles (AuNPs) conjugated with carbon nanotubes (CNTs) and/or biomolecules such as DNA are synthesized using a novel plasma technique combined with introduction of ionic liquids or aqueous solution for application to life sciences.

First, we successfully generate the gas-liquid interfacial discharge plasma (GLIDP) using an ionic liquid, in which the large sheath electric field is formed on the ionic liquid and the plasma ion irradiation to the ionic liquid with high energy is realized.

Second, it is found that the high energy ion irradiation to the ionic liquid is effective for the synthesis of the AuNPs. Furthermore, the controlled ion irradiation to the ionic liquid including a carboxyl group can realize the density-controlled synthesis of the AuNPs on the CNTs by dissociation of the ionic liquid and the controlled functionalization of the CNTs by the dissociated carboxyl group.

Third, the size- and morphology-controlled AuNPs covered with DNA are synthesized using the GLIDP with aqueous solution, where DNA prevents the AuNPs from further clustering, resulting in the small-sized AuNPs. The synthesized AuNPs conjugated with DNA can be encapsulated into the CNTs using the DC electric field. The CNTs work as vectors to deliver DNA into living cells because the CNTs have the unique ability to easily penetrate cell membranes with low cytotoxicity.

Keywords

plasma depositionnanostructurebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1469: Symposium WW – Plasma Processing and Diagnostics for Life Sciences , 2012 , mrss12-1469-ww08-01
Copyright
Copyright © Materials Research Society 2012

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References

REFERENCES

1. Meiss, S.A., Rohnke, M., Kienle, L., Abedin, S.Z.E., Endres, F., and Janek, J., ChemPhysChem 8, 50 (2007).10.1002/cphc.200600582Google Scholar
2. Hieda, J., Saito, N., and Takai, O., J. Vac. Sci. Technol. A 26, 854 (2008).10.1116/1.2919139Google Scholar
3. Kaneko, T., Baba, K., and Hatakeyama, R., J. Appl. Phys. 105, 103306 (2009).10.1063/1.3133213Google Scholar
4. Kaneko, T., Chen, Q., Harada, T., and Hatakeyama, R., Plasma Sources Sci. Technol. 20, 034014 (2011).10.1088/0963-0252/20/3/034014Google Scholar
5. Rogers, R.D. and Seddon, K.R., Science 302, 792 (2003).10.1126/science.1090313Google Scholar
6. Chen, Q., Kaneko, T., and Hatakeyama, R., J. Appl. Phys. 108, 103301 (2010).10.1063/1.3506510Google Scholar
7. Kaneko, T., Baba, K., Harada, T., and Hatakeyama, R., Plasma Proc. Polym. 6, 713 (2009).Google Scholar
8. Chen, Q., Kaneko, T., and Hatakeyama, R., Chem. Phys. Lett. 521, 113 (2012).Google Scholar
9. Pantarotto, D., Singh, R., McCarthy, D., Erhardt, M., Briand, J.-P., Prato, M., Kostarelos, K., and Bianco, A., Angew, Chem. Int. Ed. 43, 5242 (2004).Google Scholar
10. Chen, Q., Kaneko, T., and Hatakeyama, R., Curr. Appl. Phys. 11, S63 (2011).10.1016/j.cap.2011.05.022Google Scholar
11. Okada, T., Kaneko, T., Hatakeyama, R., and Tohji, K., Chem. Phys. Lett. 417, 288 (2006).10.1016/j.cplett.2005.10.030Google Scholar
12. Srivastava, S., Frankamp, B.L., and Rotello, V.M., Chem. Mater. 17, 487 (2005).10.1021/cm048579dGoogle Scholar
13. Demers, L.M., Ostblom, M., Zhang, H., Jang, N., Liedberg, B., and Mirkin, C.A., J. Am. Chem. Soc. 124, 11248 (2002).10.1021/ja0265355Google Scholar
14. Ostwald, W., Lehrbuch der Allgemeinen Chemie, Vol. 2, Part 1, (Engelmann, Leipzig, Germany, 1896).Google Scholar