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Confined Smart Hydrogels for Applications in Chemomechanical Sensors for Physiological Monitoring

Published online by Cambridge University Press:  31 January 2011

Jules J. Magda
Affiliation:
Genyao Lin
Affiliation:
[email protected], university of utah, salt lake city, Utah, United States
Prashant Tathireddy
Affiliation:
[email protected], university of utah, salt lake city, Utah, United States
Michael Orthner
Affiliation:
[email protected], university of utah, salt lake city, Utah, United States
Florian Solzbacher
Affiliation:
[email protected], university of utah, salt lake city, Utah, United States
Volker Schulz
Affiliation:
[email protected], Technische Universitat Dresden, dresden, Germany
Margarita Guenther
Affiliation:
[email protected], Technische Universitat Dresden, dresden, Germany
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Abstract

A “smart” hydrogel is a crosslinked polymer network that reversibly swells and absorbs water in response to an external stimulus such as change in pH or in the concentration of some analyte such as glucose. Microscopically-thin smart hydrogels can be combined with microfabricated piezoresistive pressure transducers to obtain “chemomechanical sensors” that serve as selective and versatile wireless biomedical sensors. Proof-of-concept is shown here using glucose- and pH-responsive hydrogels.

Type
Research Article
Copyright
Copyright © Materials Research Society 2010

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References

1 Jeong, S.Y.; Kim, S.W.; Eenink, M.J.D.; Feijen, J., “Self-regulating insulin delivery systems. I. Synthesis and characterization of glycosylated insulin”, J. Controlled Release 1, 5766 (1984).Google Scholar
2 Yager, P., “Biomedical Sensors and Biosensors”, Chap. 7.12 in Biomaterials Science. An Introduction to Materials in Medicine, Ratner, B.D.; Hoffman, A.S.; Schoen, F.J.; Lemons, J.E., eds., Academic Press, San Diego (1996).Google Scholar
3 Eggins, B., Biosensors: An Introduction, Wiley, New York (1996).Google Scholar
4 DeFrancesco, L., “Special Delivery. Making protein therapeutics more efficient requires new delivery systems”, The Scientist, pp. 3132, Feb. 24, 2003.Google Scholar
5 LaVan, D.A.; McGuire, T.; Langer, R., “Small-scale systems for in vivo drug delivery”, Nature Biotechnology 21, 11841191 (2004).Google Scholar
6 Selingo, J., “How It Works: Giving Diabetics (and Their Sore Fingers) a Break”, article in the New York Times, July 5, 2001.Google Scholar
7 Gough, D.A.; Leypoldt, J.K.; Armour, J.C., “Progress Toward a Potentially Implantable, Enzyme-Based Glucose Sensor”, Diabetes Care 5, 190198 (1982).Google Scholar
8 Reach, G.; Wilson, G.S., “Can Continuous Glucose Monitoring Be Used for the Treatment of Diabetes?”, Analytical Chem. 64, 381386A (1992).Google Scholar
9 Gough, D.A.; Armour, J.C., “Development of the Implantable Glucose Sensor. What are the Prospects and Why is it Taking So Long?”, Diabetes 44, 10051009 (1995).Google Scholar
10 Kerner, W., “Implantable glucose sensors: Present status and future developments”, Experimental & Clinical Endocrinology and Diabetes, 109 (Suppl. 2), S341–S346 (2001).Google Scholar
11 Service, R.F., “Can Sensors Make a Home in the Body?”, Science 297, 962963 (2002).Google Scholar
12 Wilson, G.S.; Hu, Y., “Enzyme-based Biosensors for in Vivo Measurements”, Chem. Rev. 100, 26932704 (2000).Google Scholar
13 Roe, J.N.; Smoller, B.R., “Bloodless Glucose Measurements”, Critical Reviews in Therapeutic Drug Carrier Systems 15, 199241 (1988).Google Scholar
14 Miyata, T.; Asami, N.; Uragami, T., “Preparation of an Antigen-Sensitive Hydrogel Using Antigen-Antibody Bindings”, Macromolecules 32, 20822084 (1999).Google Scholar
15 Miyata, T.; Asami, N.; Uragami, T., “A reversibly antigen-responsive hydrogel”, Nature 399, 766769 (1999).Google Scholar
16 Luong, J.H.T.; Bouvrette, P.; Male, K.B., “Developments and applications of biosensors in food analysis”, Trends in Biotechnolgy 6, 369377 (1988).Google Scholar
17 Brondsted, H.; Kopecek, J., “pH-Sensitive Hydrogels”, ACS Symposium Series 480 (Polyelectrolyte Gels), Harland, R.S.; Prud'homme, P.K., eds., pp. 285304 (1992).Google Scholar
18 Gehrke, S.H., “Synthesis, Equilibrium Swelling, Kinetics, Permeability and Applications of Environmentally Responsive Gels”, Advances in Polymer Sci. 110, 81144 (1993).Google Scholar
19 Dagani, R., “Intelligent Gels”, C & EN News, June 9, 1997, pp. 2637.Google Scholar
20 Galaev, I.Y.; Mattiasson, B., “Smart polymers and what they could do in biotechnology and medicine”, Trends in Biotechnology 17, 335340 (1999)Google Scholar
21 Tierney, S., Volden, S., Stokke, B.T., Glucose sensors based on a responsive gel incorporated as a Fabry-Perot cavity on a fiber-optic readout platform, Biosens. Bioelectron. 24 (2009) 20342039.Google Scholar
22 Lin, G., Chang, S., Hao, H., Tathireddy, P., Orthner, M., Magda, J., Solzbacher, F., “Osmotic swellipn pressure response of smart hydrogels suitable for chronically-implantable glucose sensors”, Sensors & Actuators B (in press).Google Scholar
23 Orthner, Michael P., Ph.D. thesis, University of Utah, 2010.Google Scholar