Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-27T02:19:10.712Z Has data issue: false hasContentIssue false
  • English
  • Français

Compositionally Modified Hydroxyapatite Nanocrystals for Polymer/Ceramic Scaffold Applications

Published online by Cambridge University Press:  26 February 2011

Andrei Stanishevsky ,
Peserai Chinoda ,
Shafiul Chowdhury ,
Vinoy Thomas ,
Aaron Catledge  and
Derrick Dean
Andrei Stanishevsky
Affiliation:
[email protected], University of Alabama at Birmingham, 1300 University Blvd., CH310, Birmingham, Alabama, 35294-1170, United States
Peserai Chinoda
Affiliation:
[email protected]
Shafiul Chowdhury
Affiliation:
[email protected]
Vinoy Thomas
Affiliation:
[email protected]
Aaron Catledge
Affiliation:
[email protected]
Derrick Dean
Affiliation:
[email protected]
Get access

Abstract

The polymer/bioceramic composite materials attract much attention for the development of bioresorbable implants and tissue engineering scaffolds. Hydroxyapatite (HA) is the most commonly used bioceramic material due to its similarity to the major mineral component of the hard tissue. We synthesized carbonated and Mg-substituted HA nanocrystals with various concentrations of CO32− and Mg2+ ions by chemical precipitation in the range of the process temperatures from 25 °C to 100 °C.

The HA nanocrystals were mixed with several polymeric materials (PCL, PLA, PVA, collagen) to fabricate bulk and nanofiber polymer/HA nanoparticle composites with the HA loading up to 80 % by weight. The HA nanocrystals and polymer/HA composites were characterized by X-ray diffraction, FT-IR spectroscopy, scanning electron and atomic force microscopy. Mechanical properties of the composites were investigated using nanoindentation technique.

Keywords

polymerceramicnanoscale
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 897: Symposium J – Biomemetic Polymers and Gels , 2005 , 0897-J03-18
Copyright
Copyright © Materials Research Society 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Rikli, D.A., Regazzoni, P., and Perren, S.M., Injury, Int. J. Care Injured 33, 2 (2002).Google Scholar
2. Lewandrowski, K.U., Bondre, S.P., Shea, M., Untch, C.M., Hayes, W.C., Hile, D.D., Wise, D.L., and Trantolo, D.J., J. BioMedical Mater. Eng. 12, 423 (2002).Google Scholar
3. Pietrzak, W.S., Tissue Eng. 6, 425 (2000).Google Scholar
4. Hench, L.L., and Polak, J.M., Science 295, 1014 (2000).Google Scholar
5. Mano, J.F., Sousa, R.A., Boesel, L.F., Neves, N.M., and Reis, R.L., Composites Sci. Technol. 64, 789 (2004).Google Scholar
6. Liu, Q., deWijn, J.R., and van Blitterswijk, C.A., Biomat. 18, 1263 (1997).Google Scholar
7. McManus, A.J., Doremus, R.H., Siegel, R.W., and Bizios, R., J. Biomed. Mater. Res. 72A, 98 (2005).Google Scholar
8. Wei, G.B., and Ma, P.X., Biomat. 25, 4749 (2004).Google Scholar
9. Tanaka, Y., Hirata, Y., and Yoshinaka, R., J. Ceram. Proc. Res. 4, 197 (2003).Google Scholar
10. Mathews, J.A., Wnek, G.E., Simpson, D.G., and Bowlin, G.L., Biomacromol. 3, 232 (2002).Google Scholar
11. Suryanarayana, C., and Norton, M.G., X-ray diffraction, a practical approach(Plenum Press, New York 1998) pp.207–222.Google Scholar
12. Chowdhury, S., Thomas, V., Dean, D., Catledge, S.A., and Vohra, Y.K., J. Nanosci. Nanotechnol. 5, 1816 (2005).Google Scholar
13. Oliver, W.C., and Pharr, G.M., J. Mater. Res. 7, 1564 (1992).Google Scholar