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Characterization and Applications of Modulated Optical Nanoprobes (MOONs)

Published online by Cambridge University Press:  01 February 2011

Jeffrey N. Anker ,
Caleb J. Behrend ,
Brandon H. McNaughton ,
Teresa Gail Roberts ,
Murphy Brasuel ,
Martin A. Philbert  and
Raoul Kopelman
Jeffrey N. Anker
Affiliation:
University of Michigan Chemistry Department, Ann Arbor, Michigan 48109–1055.
Caleb J. Behrend
Affiliation:
University of Michigan Chemistry Department, Ann Arbor, Michigan 48109–1055.
Brandon H. McNaughton
Affiliation:
University of Michigan Chemistry Department, Ann Arbor, Michigan 48109–1055.
Teresa Gail Roberts
Affiliation:
University of Michigan Chemistry Department, Ann Arbor, Michigan 48109–1055.
Murphy Brasuel
Affiliation:
Colarado College Chemistry Department, Colorado Springs, Colorado 80903.
Martin A. Philbert
Affiliation:
University of Michigan School of Public Health, Ann Arbor, Michigan 48109.
Raoul Kopelman
Affiliation:
University of Michigan Chemistry Department, Ann Arbor, Michigan 48109–1055.
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Abstract

Modulated optical nanoprobes (MOONs) are microscopic (spherical and aspherical) particles designed to emit different fluxes of light in a manner that depends on particle orientation. When particle orientation is controlled remotely using magnetic fields (MagMOONs) it allows modulation of fluorescence intensity in any selected pattern including square and sinusoidal waves. The broad range of sizes over which MOONs can be prepared allows them to be tailored to applications from intracellular sensors using submicron MOONs to immunoassays using larger MOONs (1–10μm). In the absence of external fields, or material that responds to external fields, the particles tumble erratically due to Brownian thermal forces. These erratic changes in orientation cause the MOONs to blink. The temporal pattern of blinking contains information about the local rheological environment and any forces and torques acting on the MOONs.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 790: Symposium P – Dynamics in Small Confining Systems–2003 , 2003 , P4.1
Copyright
Copyright © Materials Research Society 2004

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