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Published online by Cambridge University Press: 21 February 2011
Recently the first experiments in magnetic resonance force microscopy (MRFM) have been conducted. In these experiments a force microscope cantilever is used to detect the magnetic force exerted by electrons and nuclei in a sample. The magnetization of the sample is modulated at the resonant frequency of the cantilever, using standard magnetic resonance techniques. The resulting excitation of the cantilever is detected optically. This article reviews the present status of MRFM technology, emphasizing the physical principles involved and the opportunities for further research and development. Particular emphasis is placed on single spin detection by MRFM and potential applications in biomolecular imaging.