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BLM-Based Electrochemical Sensors

Published online by Cambridge University Press:  15 February 2011

A. Leitmannova-Ottova
Affiliation:
Membrane Biophysics Lab (Giltner Hall) Department of Physiology Michigan State University, East Lansing, MI 48824 (USA)
W. Liu
Affiliation:
Membrane Biophysics Lab (Giltner Hall) Department of Physiology Michigan State University, East Lansing, MI 48824 (USA)
T.-A. Zhou
Affiliation:
Membrane Biophysics Lab (Giltner Hall) Department of Physiology Michigan State University, East Lansing, MI 48824 (USA)
H. T. Tien*
Affiliation:
Membrane Biophysics Lab (Giltner Hall) Department of Physiology Michigan State University, East Lansing, MI 48824 (USA)
*
*To whom all correspondence should be addressed.
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Abstract

Bilayer lipid membranes (BLMs), especially self-assembled bilayer lipid membranes on solid supports (s-BLMs), have been used in the last three years as lipid bilayer-based biosensors. In this paper, we will describe as well as review briefly our work on s-BLMs and closely related systems including the preparation and characterization of s-BLMs, hydrogen peroxide-sensitive electrodes based on s-BLMs, alkaline-pretreated aluminum electrodes as pH sensors, immobilization of ferrocene on a s-BLM as anamperometric sensor of Fe(CN)63-/4- ions, cyclic voltanmmetry studies of s-BLMs modified with electron mediators, TCPBQ/TCOBQ modified s-BLMs for pH measurements, TCNQ-modified s-BLMs for glucose detection, and s-BLMs on interdigital electrodes prepared by microelectronic techniques.

Type
Research Article
Copyright
Copyright © Materials Research Society 1994

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Footnotes

1

Center for Interface Sciences, Department of Microelectronics

2

Slovak Technical University, Bratislava, Slovak Republic. On leave from the Department of Chemistry, Jilin University, Changchun, P. R. China.

3

Department of Chemistry, Hunan University, Changsha, P. R. China.

References

REFERENCES

1. Tien, H. T., Guo, D.-L., and Ottova-Leitmannova, A., in “Signal Transduction and Information Processing in Biological Systems,” by USARO Workshop, Cashiers, April 1992. (eds Campbell, R.J. and Tove, S. R.). pp. 51–67.Google Scholar
2. Ottova-Leitmannova, A., Martynski, T., Wardak, A. and Tien, H. T., in Molecular Electronics and Bioelectronics (Birge, R., ed.) Adv. Chem. Series No. 240, ACS, Washington, D. C. (1993).Google Scholar
3. Abidor, I. G., Arakelyan, V. B., Chernomordik, L. V., Chizmadzhev, Ye. A., Pastushenko, V. F. and Tarassvich, M. R., Bioelectrochem. Bioenerg., 6, 37 (1979).Google Scholar
4. Tien, H. T., Prog. Surf. Sci., 19, 169274 (1985).CrossRefGoogle Scholar
5. Chernomordik, L. V., Melikyan, G. B., Chizmadzhev, Y. A., Biochim. Biophys. Acta, 906, 309 (1987).CrossRefGoogle Scholar
6. Gallez, D., Printo, N. M. C., Bisch, P. M., J. Coll. Int. Sci., 160, 141 (1993).Google Scholar
7. Bulaychev, A. I. and Torgov, V. G., Coll. J. Rev., 55, 20 (1993).Google Scholar
8. Shchipunov, Y. A. and Shumilinov, E. V., J. Coll. Int. Sci., 161, 125 (1993).CrossRefGoogle Scholar
9. Tien, H. T., ”Self-assembled lipid bilayers for biosensors and molecular electronic devices,” Advanced Materials, 2, 316318, June 1990.Google Scholar
10. Ottova-Leitmannova, A. and Tien, H. T., Prog. Surface Science, 41(4) 337445 (1992).CrossRefGoogle Scholar
11. Schulmann, W., Heyn, S.-P. and Gaub, H. E., Adv. Materials, 3, 388 (1991).Google Scholar
12. Hianik, T., Dlugopolsky, J. and Gyepessova, M., Bioelectrochem. Bioeng., 31, 99 (1993).Google Scholar
13. Kinnear, K. T. and Monbouquette, H. G., Langmuir, 9, 2255 (1993).CrossRefGoogle Scholar
14. Tien, H. T., Salamon, Z., Liu, W. and Ottova, A., Analyt. Lett., 26, 819 (1993).CrossRefGoogle Scholar
15. Tien, H. T., Bilayer Lipid Membranes (BLM): Theory and Practice, Dekker, Inc., New York, 1974.Google Scholar
16. Liu, W., Ottova-Leitmannova, A. and Tien, H. T., in “Polymer/Inorganic Interfaces”, Vol.304 (Opila, R. L., Boerio, F. J. and Czanderna, A. W., eds) Materials Research Society, Pittsburgh (1993).Google Scholar
17. Ziegler, W., Remis, D., Brunovska, A. and Tien, H. T., in Proc. 7th C-S Conference on Thin Films, (Tvarozek, V. and Nemeth, S., Eds.) pp. 304–311.Google Scholar
18. Tien, H. T., Salamon, Z., Kutnik, J., Krysinski, P., Kotowski, J., Ledermann, D. and Janas, T., ”Bilayer lipid membranes (BLM): an experimental system for biomolecular electronic device development,” J. of Molecular Electronics, Vol. 4, S1–S30, (1988).Google Scholar
19. Kotowski, J., Janas, T., and Tien, H. T., ”Immobilization of glucose oxidase on a polypyrrole-lecithin bilayer lipid membrane,” Bioelectrochemistry and Bioenergeties, 19, pp. 277282, sec. of J. Electroanal. Chem., Vol.253, (1988).CrossRefGoogle Scholar
20. Zhou, T.-A., Ottova, A. and Tien, H. T., J. Electrochem. Soc., submitted (1993).Google Scholar
21. Ziegler, W., Remis, D., Brunovska, A., Jakabovic, J. and Tien, H. T., in Proc. 7th C-S Conference on Thin Films, L. Mikulas, Slovakia, June 1993. pp. 308–311.Google Scholar