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Biphasic Polymeric Shell-Core 3D Fiber Deposited Scaffolds Enhance Chondrocyte Differentiation

Published online by Cambridge University Press:  01 February 2011

Lorenzo Moroni ,
Jeanine A.A. Hendriks ,
Roka Schotel ,
Joost R. de Wijn  and
Clemens A. van Blitterswijk
Lorenzo Moroni
Affiliation:
[email protected], Twente University, Polymer Chemistry and Biomaterials, Prof. Bronkhorstlaan 10D, Bilthoven, Utrecht, 3581 KH, Netherlands, +31302295201, +31302280255
Jeanine A.A. Hendriks
Affiliation:
[email protected], University of Twente, Polymer Chemistry and Biomaterials, Prof. Bronkhorstlaan 10D, Bilthoven, Utrecht, 3723 MB, Netherlands
Roka Schotel
Affiliation:
[email protected], CellCoTec B.V., Prof. Bronkhorstlaan 10D, Bilthoven, Utrecht, 3723 MB, Netherlands
Joost R. de Wijn
Affiliation:
[email protected], University of Twente, Polymer Chemistry and Biomaterials, Prof. Bronkhorstlaan 10D, Bilthoven, Utrecht, 3723 MB, Netherlands
Clemens A. van Blitterswijk
Affiliation:
[email protected], University of Twente, Polymer Chemistry and Biomaterials, Prof. Bronkhorstlaan 10D, Bilthoven, Utrecht, 3723 MB, Netherlands
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Abstract

3D fibrous scaffolds with shell-core fiber architecture offer the possibility to create multifunctional structures. In this study, a construct that combines mechanical stability with the core polymer and optimal surface properties for cell-material interactions with the shell polymer is discussed. Scaffolds were fabricated by a rapid prototyped technique known as 3D Fiber Deposition (3DF) and used for cartilage tissue engineering. Cells maintained the typical rounded morphology of cartilage in the shell-core scaffolds, while they spread into a spindle-like shape in scaffolds fabricated with the core polymer only. Extracellular matrix production and an increase in the dynamic stiffness of the engineered construct revealed a progressive maturation of the formed tissue, suggesting that shell-core 3D scaffolds could be optimal for cartilage tissue engineering.

Keywords

morphologypolymeradhesion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 925: Symposium BB – Mechanotransduction and Engineered Cell-Surface Interactions , 2006 , 0925-BB03-03
Copyright
Copyright © Materials Research Society 2006

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References

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