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Biological Properties of Nanocrystalline Silicon Particles for Biomedical Applications

Published online by Cambridge University Press:  01 February 2011

Keisuke Sato ,
Satoshi Yanagisawa ,
Akio Funakubo ,
Yasuhiro Fukui ,
Kenji Hirakuri  and
Tetsuya Higami
Keisuke Sato
Affiliation:
[email protected], Tokyo Denki University, Department of Electronic and Computer Engineering, Ishizaka, Hatoyama, Hikigun, Saitama, 350-0394, Japan, +81-49-296-2911, +81-49-296-6413
Satoshi Yanagisawa
Affiliation:
[email protected], Tokyo Denki University, Department of Electronic and Computer Engineering, Ishizaka, Hatoyama, Hikigun, Saitama, 350-0394, Japan
Akio Funakubo
Affiliation:
Tokyo Denki University, Department of Electronic and Computer Engineering, Ishizaka, Hatoyama, Hiki gun, Saitama, 350-0394, Japan
Yasuhiro Fukui
Affiliation:
Tokyo Denki University, Department of Electronic and Computer Engineering, Ishizaka, Hatoyama, Hikigun, Saitama, 350-0394, Japan
Kenji Hirakuri
Affiliation:
[email protected], Tokyo Denki University, Department of Electronic and Computer Engineering, Ishizaka, Hatoyama, Hikigun, Saitama, 350-0394, Japan
Tetsuya Higami
Affiliation:
Sapporo Medical University, Department of Second Surgery, South 1 West 17 Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan
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Abstract

We have studied the biological properties of nanocrystalline silicon (nc-Si) particles after injection at various places in a mouse. The nc-Si particles with a size of 2.5 nm and a concentration of 1.3 mg/ml were dispersed in a normal saline solution (NSS). The NSS dispersible nc-Si particles were safely injected into the mouse. When the nc-Si particles in the NSS were directly injected into the subcutaneous vein and the coronary artery of the heart by syringe, the condition of bloodstream at each place was confirmed by the red luminescence (peak wavelength at 720 nm) from the nc-Si particles under the ultraviolet (UV) light-irradiation. Moreover, the nc-Si particles in the NSS, which were injected into the vein in the sole, smoothly flowed to the small intestine, and the smooth fluidity of nc-Si particles was also observed for the condition of the peristalsis of the small intestine. The nc-Si particles in the small intestine emitted red light during peristalsis under the UV light-irradiation. The red luminescence at each place was very bright and could be clearly seen with the naked eye. These phenomenons were achieved by the utilization of the harmless material, the formation of nc-Si particles with the single-order-size and the realization of the stable surface modification to the nc-Si particles.

Keywords

nanostructurebiologicalbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 958: Symposium L – Group IV Semiconductor Nanostructures—2006 , 2006 , 0958-L10-19
Copyright
Copyright © Materials Research Society 2007

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References

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