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Bioinspired Artificial Protein Materials: Self-Assembly and Order from Nano to Macroscale

Published online by Cambridge University Press:  10 March 2011

Min Dai ,
Jennifer S. Haghpanah ,
Carlo Yuvienco  and
Jin Kim Montclare
Min Dai
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Jennifer S. Haghpanah
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Carlo Yuvienco
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Jin Kim Montclare
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A. SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, U.S.A.
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Abstract

We describe the biosynthesis and characterization of protein materials comprised of two distinct self-assembling domains (SADs): elastin (E) found in tissue for its elastic properties and cartilage oligomeric matrix protein coiled-coil (COMPcc, C) predominantly locatedin joint and in bones. Based on earlier studies on protein block polymers comprised these two SADs, orientation and number of blocks play a crucial role in the overall stimuli-responsive supramolecular assembly behavior. Here we fabricate a range of EnC and CEn block polymers in which the E domain is systematically truncated to explore the effects of the E domain on the overall physicochemical behavior.

Keywords

biomaterialbiological synthesis (assembly)biomimetic (assembly)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1301: Symposium V/NN/OO/PP – Soft Matter, Biological Materials and Biomedical Materials—Synthesis, Characterization and Applications , 2011 , mrsf10-1301-oo11-04
Copyright
Copyright © Materials Research Society 2011

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References

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