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Biocompatibility of Polyurethane Urea Elastomers for Cardiac Tissue Engineering

Published online by Cambridge University Press:  19 March 2012

A. Paredes-Puerto ,
D. Dashti ,
Y. Yeghiazarians ,
K.E. Healy  and
F. Hernández-Sánchez
A. Paredes-Puerto
Affiliation:
Unidad de Materiales, Centro de Investigación Científica de Yucatán (CICY), Calle 43 No. 103, Col. Chuburna de Hidalgo, C.P.97200, Mérida, Yucatán, México. Department of Bioengineering, University of California at Berkeley, Berkeley, California, 94720, U.S.A.
D. Dashti
Affiliation:
Department of Bioengineering, University of California at Berkeley, Berkeley, California, 94720, U.S.A.
K.E. Healy
Affiliation:
Department of Bioengineering, University of California at Berkeley, Berkeley, California, 94720, U.S.A. Department of Material Science and Engineering, University of California at Berkeley, Berkeley, California, 94720 U.S.A.
F. Hernández-Sánchez
Affiliation:
Unidad de Materiales, Centro de Investigación Científica de Yucatán (CICY), Calle 43 No. 103, Col. Chuburna de Hidalgo, C.P.97200, Mérida, Yucatán, México.
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Abstract

Cardiac disease is the main cause of death in men and women in México and the U.S.A. When heart muscle suffers an injury, i.e. cardiac infarction, the tissue dies and is replaced by a fibrotic scar that does not allow for normal organ function. To alleviate scar tissue, the objective of this work was to investigate and synthesize polyurethane ureas from polycaprolactone diol, methylene bis(4-cyclohexilisocyanate), and butanediamine with different hard segment contents, characterize them, and prove their biocompatibility by seeding SCA-1+/CD45- cardiac progenitor cells obtained from mice cardiospheres. Ultimately, this work aims to explore how polyurethane urea elastomers can aid in therapeutic cardiac tissue regeneration.

Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1376: Symposium S11 – Biomaterials for Medical Applications , 2012 , imrc11-1376-s11-p30
Copyright
Copyright © Materials Research Society 2012

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References

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