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Biocompatibility Comparison of Stainless Steel, Gold-Coated, and Heat-Treated Gold-Coated Endovascular Stents

Published online by Cambridge University Press:  17 March 2011

Alisa S. Morss ,
Philip Seifert ,
Adam Groothius ,
Danielle Bornstein ,
Campbell Rogers  and
Elazer R. Edelman
Alisa S. Morss
Affiliation:
Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, MA 02139
Philip Seifert
Affiliation:
Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, MA 02139
Adam Groothius
Affiliation:
Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, MA 02139
Danielle Bornstein
Affiliation:
Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, MA 02139
Campbell Rogers
Affiliation:
Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, MA 02139
Elazer R. Edelman
Affiliation:
Harvard-M.I.T. Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, MA 02139
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Abstract

Endovascular stents can be altered to improve radioopacity by applying a gold coating. We examined the vascular response in porcine coronary arteries to implantation of 9 mm NIR® stents that were either left intact, gold-coated, or heat-treated following gold coating. Our results show that while gold coating exacerbates neointimal hyperplasia and the inflammatory response, heat treatment removes this negative effect. Heat treatment was shown to increase the diffusion at the gold-steel interface and reduce the surface roughness.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 711: Symposia FF/GG/HH – Advanced Biomaterials--Characterization, Tissue Engineering and Complexity , 2001 , FF1.9.1
Copyright
Copyright © Materials Research Society 2002

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References

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