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Bioactive Polypyrrole Thin Films with Conductimetric Response to Analyte

Published online by Cambridge University Press:  10 February 2011

A. Guiseppi-Elie ,
J. M. Tour ,
D. L. Allarat  and
N. F. Sheppard Jr.
A. Guiseppi-Elie
Affiliation:
Research and Development Department, Aai-Abtech, Yardley, PA 19067 Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208
J. M. Tour
Affiliation:
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208
D. L. Allarat
Affiliation:
Materials Research Institute, The Pennsylvania State University, University Park, PA 16802
N. F. Sheppard Jr.
Affiliation:
Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21218
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Abstract

Thin films of electroconductive poly[pyrrole-co-3−(1−pyrrolyl)propionic acid] were prepared by electropolymerization onto 3-aminopropyltrimethoxysilane modified and 3−(1−pyrrolyl)propionic acid derivatized interdigitated microsensor electrode (IME) arrays. The ω−(1−pyrrolyl) moiety on the surface of the device provides for specific adhesion of the polymer film to the device and the (N-pyrrolyl)propionic acid moiety on the polymer backbone provides for covalent attachment of bioactive molecules, such as biotin and urease, to the polymer surface. The immobilized, bioactive urease produces an ON/OFF conductimetric response traceable to analyte concentration.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 413: Symposium W – Electrical, Optical, and Magnetic Properties of Organic Solid State Materials III , 1995 , 439
Copyright
Copyright © Materials Research Society 1996

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References

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