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Architectural changes of trabecular bone caused by the remodeling process

Published online by Cambridge University Press:  01 February 2011

Richard Weinkamer ,
Markus A. Hartmann ,
Yves Brechet  and
Peter Fratzl
Richard Weinkamer
Affiliation:
Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Potsdam, Germany
Markus A. Hartmann
Affiliation:
Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Potsdam, Germany
Yves Brechet
Affiliation:
ENSEEG, LTPCM, Domaine Universitaire de St. Martin d'Hères, Cedex, France
Peter Fratzl
Affiliation:
Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Potsdam, Germany Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria
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Abstract

Using a stochastic lattice model we have studied the architectural changes of trabecular bone occurring while the structure is remodeled. Our model considers the mechanical feedback loop, which control the remodeling process. A fast algorithm was employed to solve approximately the mechanical problem. A general feature of the model is that a networklike structure emerges, which further coarsens while the bone volume fraction remains unchanged. Decreasing the mechanical response of the system by either lowering the external load or the internal mechano-sensitivity leads not only to a reduction of the bone volume fraction, but results in topological changes of the trabecular bone architecture, where the loss of horizontal trabeculae is the most obvious effect.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 874: Symposium l – Structure and Mechanical Behavior of Biological Materials , 2005 , L1.9
Copyright
Copyright © Materials Research Society 2005

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References

1. Meulen, M. C. H. van der and Huiskes, R., Journal of Biomechanics, 35, 401, (2002)Google Scholar
2. Jee, W. S., Integrated Bone Tissue Physiology: Anatomy and Physiology, in Bone Mechanics Handbook, Cowin, S. C., Editor. 2001, CRC Press.Google Scholar
3. Huiskes, R., Ruimerman, R., Lenthe, G. H. van and Janssen, J. D., Nature, 405, 704, (2000)Google Scholar
4. Weinkamer, R., Hartmann, M. A., Brechet, Y. and Fratzl, P., Physical Review Letters, 93, 228102, (2004)Google Scholar
5. Homminga, J., Van-Rietbergen, B., Lochmuller, E. M., Weinans, H., Eckstein, F. and Huiskes, R., Bone, 34, 510, (2004)Google Scholar
6. Parkinson, J., Brass, A., Canova, G. and Brechet, Y., Journal of Biomechanics, 30, 549, (1997)Google Scholar
7. Frost, H. M., Anat Rec, 219, 1, (1987)Google Scholar
8. Gibson, L. J. and Ashby, M. F., Cellular solids: structure and properties. 2nd ed. Cambridge solid state science series. 1997, Cambridge; New York: Cambridge University Press.Google Scholar
9. Morgan, E. F., Bayraktar, H. H. and Keaveny, T. M., Journal of Biomechanics, 36, 897, (2003)Google Scholar
10. Woesz, A., Stampfl, J. and Fratzl, P., Advanced Engineering Materials, 6, 134, (2004)Google Scholar