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The Application of a New Composite in Large Bone Defects using Fibrillar Collagen and HA/TCP

Published online by Cambridge University Press:  26 February 2011

Masaaki Uratsuji ,
T. W. Bauer  and
S. I. Reger
Masaaki Uratsuji
Affiliation:
Department of Musculoskeletal ResearchThe Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44106
T. W. Bauer
Affiliation:
Department of PathologyThe Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44106
S. I. Reger
Affiliation:
Department of Musculoskeletal ResearchThe Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44106
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Extract

The handling property and short term biological response to a new composite of fibrillar collagen (FC) and porous calcium phosphate (HA/TCP) were studied. A 4 mm by 20 mm defect was created in the femora of rabbits. The rabbits were divided into four treatment groups and sacrificed from each group at 4, 8 and 12 weeks. In each group, the defect was treated as follows: in Group I with autogenous bone marrow; in Group II with FC and HA/TCP; and in Group III with FC and HA/TCP with bone marrow in volume ratio of 3:1. In the fourth group, the defect was unfilled. The femora were excised and studied by microradiography or histology or both. The FC could improve the handling property of the HA/TCP granules. Although the composite of FC and HA/TCP was not osteoinductive, the defects in Groups II and III showed good healing at 12 weeks without signs of inflammation. The results showed the composite of FC and HA/TCP to be an effective filler for large bone defects especially when mixed with autogenous bone marrow.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 199
Copyright
Copyright © Materials Research Society 1988

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References

1. Lew, D., Clark, R.J. and Jimenez, F., J. Oral Maxillofac. Surg., 44, 606 (1986)CrossRefGoogle Scholar
2. Block, M.S., Zide, M.F. and Kent, J.N., J. Oral Maxillofac. Surg., 44, 244 (1986)Google Scholar
3. Kent, J.N., Zide, M.F., Kay, J.F. and Jarco, M., J. Oral Maxillofac. Surg., 44, 597 (1986)Google Scholar
4. Hollinger, J.O. and .Battistone, C., Clin. Orthop., 207, 290 (1986)Google Scholar
5. Jarco, M., Clin. Orthop., 157, 259 (1981)Google Scholar
6. Klein, C.P.A.T., Lubbe, H.B.M. van der and Groot, K. de, Biomaterials, 8, 308 (1987)Google Scholar
7. Claes, L.E., Trans. 12th Ann. Meet. Soc. Biomater. 1986, p. 214Google Scholar
8. Dahners, L.E., Jacobs, R.R., Kliethermes, J.L., Wetzel, L.H. and Rhoades, C.E., Orthopedics, 7, 984 (1984)Google Scholar
9. Moore, D.C., Chapman, M.W. and Manske, D., J. Orthop. Res. , 5, 356 (1987)Google Scholar
10. Paley, D., Young, M.C., Wiley, A.M., Fornasier, V.L. and Jackson, R.W., Clin. Orthop., 208, 300 (1986)CrossRefGoogle Scholar
11. Shapoff, C.A., Bowers, G.M., Levy, B., Mellonig, J.T. and Yukna, R.A., J. Periodontal, 51, 625 (1980)CrossRefGoogle Scholar
12. DeLustro, F., Smith, S.T., Sundsmo, J., Salem, G., Kincaid, S. and Ellingsworth, L., Plast. Reconstr. Surg., 79, 581 (1986)Google Scholar
13. Salama, R., Clin. Orthop., 174, 113 (1983)CrossRefGoogle Scholar
14. Salama, R. and Weissman, S.L., J. Bone Joint Surg., 60B, 111 (1978)Google Scholar
15. Uchida, A., Nade, S., McCartney, E. and Ching, W., J. Biomed. Mater. Res., 21, 1 (1987)Google Scholar
16. Nade, S., Armstrong, L., McCartney, E. and Baggaley, B., Clin. Orthop., 181, 255 (1983)CrossRefGoogle Scholar
17. Urist, M.R., Nilsson, O., Rasmussen, J., Hirota, W., Lovell, T., Schmalzreid, T. and Finerman, G.A.M., Clin. Orthop., 214, 295 (1987)Google Scholar
18. Block, M.S. and Kent, J.N., J. Oral Maxillofac. Surg., 43, 3 (1985)Google Scholar