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An Investigation of Nano-structured Polymers for Use as Bladder Tissue Replacement Constructs

Published online by Cambridge University Press:  17 March 2011

Anil Thapa ,
Thomas J. Webster  and
Karen M. Haberstroh
Anil Thapa
Affiliation:
Department of Biomedical EngineeringPurdue University, West Lafayette, Indiana 47907-1296
Thomas J. Webster
Affiliation:
Department of Biomedical EngineeringPurdue University, West Lafayette, Indiana 47907-1296
Karen M. Haberstroh
Affiliation:
Department of Biomedical EngineeringPurdue University, West Lafayette, Indiana 47907-1296
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Abstract

Conventionally, studies investigating the design of synthetic bladder wall substitutes have involved polymers with micro-dimensional structures. Since the body is made up of nano-structured components (e.g., extracellular matrix proteins), our focus has been in the use of nano-structured polymers in order to design a three-dimensional synthetic bladder construct that mimics bladder tissue in vivo. In order to complete this task, we fabricated novel, nano-structured, biodegradable materials to serve as substrates for bladder tissue constructs and tested the cytocompatibility properties of these biomaterials in vitro. The results from our in vitro work to date have provided the first evidence that cellular responses (such as adhesion and proliferation) of bladder smooth muscle cells are enhanced as poly (lactic-co-glycolic acid) (PLGA) surface feature dimensions are reduced into the nanometer range.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 711: Symposia FF/GG/HH – Advanced Biomaterials--Characterization, Tissue Engineering and Complexity , 2001 , GG3.4.1
Copyright
Copyright © Materials Research Society 2002

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References

REFERENCES

1. Greenlee, R.T., Murray, T., Bolden, S., and Wingo, P.A., CA Cancer J. Clin. 50, 7–33 (2000).Google Scholar
2. Fleshner, N.E. and Herr, H.W., Cancer 78, 1505–13 (1996).Google Scholar
3. Melekos, M.D. and Moutzouris, G.D., Curr. Pharm. Des. 6, 345–59 (2000).Google Scholar
4. Atala, A., Freeman, M.R., Vacanti, J.P., Shepard, J., and Retik, A.B., The Journal of Urology 150, 608–612 (1993).Google Scholar
5. Gleeson, M.J. and Griffith, D.P., The Journal of Urology 148, 1377–1382 (1992).Google Scholar
6. Elbahnasy, A.M., Shalhav, A., Hoenig, D.M., Figenshau, R., and Clayman, R.V., The Journal of Urology 159, 628–637 (1998).Google Scholar
7. Haberstroh, K.M., Kaefer, M., Retik, A.B., Freeman, M.R., and Bizios, R., The Journal of Urology 162(6), 2114–2118 (1999).Google Scholar
8. Gao, J., Niklason, L., and Langer, R., J. Biomed. Mat. Res. 42(3), 417–424 (1998).Google Scholar