Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-27T01:48:24.404Z Has data issue: false hasContentIssue false
  • English
  • Français

Adhesion Kinetics of MC3T3-E1 Pre-Osteoblasts to Osteoconductive Porous Titanium Scaffolds

Published online by Cambridge University Press:  17 March 2011

Jean-Philippe St-Pierre ,
Maxime Gauthier ,
Louis-Philippe Lefebvre  and
Maryam Tabrizian
Jean-Philippe St-Pierre
Affiliation:
McGill University, Department of Biomedical Engineering, Montreal, Canada National Research Council Canada, Industrial Materials Institute, Boucherville, Canada
Maxime Gauthier
Affiliation:
National Research Council Canada, Industrial Materials Institute, Boucherville, Canada
Louis-Philippe Lefebvre
Affiliation:
National Research Council Canada, Industrial Materials Institute, Boucherville, Canada
Maryam Tabrizian
Affiliation:
McGill University, Department of Biomedical Engineering, Montreal, Canada
Get access

Abstract

Porous metallic scaffolds have recently gained recognition as a promising avenue toward the regeneration of damaged bone structures. Interest in these materials resides in their ability to guide bone growth by presenting a favorable structure for cellular adhesion and three-dimensional proliferation. A powder metallurgy process to fabricate titanium foams with favorable microstructural parameters for applications in bone engineering has recently been developed. This study assesses the potential of this novel material for applications as an osteoconductive scaffold through in vitro characterization of early cellular interactions with titanium foams having pore sizes ranging from 167 to 500 µm. The foams exhibit no cytotoxic effects on J774 mouse macrophages while favoring adhesion and proliferation of MC3T3-E1 pre-osteoblasts. Three-dimensional morphology assumed by these cells on porous titanium suggests that the microstructure of the foams is biomimetic.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 823: Symposium W – Biological and Bioinspired Materials and Devices , 2004 , W12.9
Copyright
Copyright © Materials Research Society 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Welsh, R.P., Pilliar, R.M. and Macnab, I., J. Bone Joint Surg. 53A, 963 (1971).Google Scholar
2. Galante, J., Rostoker, W., Lueck, R. and Ray, R.D., J. Bone Joint Surg. 53A, 101 (1971).CrossRefGoogle Scholar
3. Hahn, H. and Palich, W., J. Biomed. Mater. Res. 4, 571, 1970.Google Scholar
4. Bobyn, J.D., Stackpool, G.J., Hacking, S.A., Tanzer, M. and Krygier, J.J., J. Bone Joint Surg. 81B, 907 (1999).Google Scholar
5. Curodeau, A., Sachs, E. and Caldarise, S., J. Biomed. Mater. Res. (Appl. Biomater.). 53, 525 (2000).3.0.CO;2-1>CrossRefGoogle Scholar
6. Lefebvre, L.P. and Thomas, Y., U.S. Patent No. 6 660 224 (9 December 2003).Google Scholar
7. Gauthier, M., Menini, R., Bureau, M.N., So, S.K.V., Dion, M.J. and Lefebvre, L.P., presented at the 2003 ASM Materials and Processes for Medical Devices Conference, Anaheim, CA, 2003 (to be published in the proceedings).Google Scholar
8. St-Pierre, J.P., Gauthier, M., Lefebvre, L.P. and Tabrizian, M., presented at the 2003 Canadian Biomaterials Society, Montreal, QC, 2003 (unpublished).Google Scholar
9. Linez-Bataillon, P., Monchau, F., Bigerelle, M. and Hildebrand, H.F., Biomol. Eng. 19, 133 (2002).Google Scholar
10. Anselme, K., Biomaterials. 21, 661 (2000).Google Scholar
11. Schmidt, C., Kaspar, D., Sarkar, M.R., Claes, L.E. and Ignatius, A.A., J. Biomed. Mater. Res. (Appl. Biomater.). 63, 252 (2002).Google Scholar
12. Yang, Y., Tian, J., Deng, L. and Ong, J.L., Biomaterials. 23, 1383 (2002).Google Scholar