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Use of a Multiple Lumen Cuff for Nerve Regeneration

Published online by Cambridge University Press:  15 February 2011

Raymond Greer ,
John Daniel ,
Etsuro Uemura ,
Raymond Kudej ,
Yueh-Sheng Chen  and
Chih-Hui Chung
Raymond Greer
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011 Engineering Research Institute, Iowa State University, Ames, IA 50011
John Daniel
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
Etsuro Uemura
Affiliation:
Veterinary Anatomy, Iowa State University, Ames, IA 50011
Raymond Kudej
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
Yueh-Sheng Chen
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
Chih-Hui Chung
Affiliation:
Biomedical Engineering Program, Iowa State University, Ames, IA 50011
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Abstract

Initial studies using the rat sciatic nerve demonstrated the ability to adapt a multiple lumen cuff face to a nerve stump repair site. The neurons in the proximal stump grew through the individual conduits of the silicone rubber cuff, crossed a 5 mm gap, and continued into the distal stump. The effect of the cuff design on axonal regeneration was studied by comparing macroscopic and microstructural results for experimental groups of Sprague-Dawley rats with controls at 8, 12, 16, and 24 weeks post-implantation. The several individual nerve bundles which formed within the cuff lumens during these periods maintained their alignment on the distal side of the gap. The use of the multiple lumen system provided suitable scaffolding support and control of orientation and direction for fibers and established a sized, controlled environment for regeneration within each of the separate nerve cuff compartments.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 3
Copyright
Copyright © Materials Research Society 1994

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