Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-03T02:13:59.107Z Has data issue: false hasContentIssue false
  • English
  • Français

Topographical Evolution of Nanocrystalline Diamond and Its Effect on Osteoblast Interactions

Published online by Cambridge University Press:  01 February 2011

Lei Yang ,
Brian W Sheldon  and
Thomas J Webster
Lei Yang
Affiliation:
[email protected], Brown University, Divsion of Engineering, 182 Hope Street, Box D, Providence, RI, 02912, United States
Brian W Sheldon
Affiliation:
[email protected], Brown University, Divsion of Engineering, 182 Hope Street, Providence, RI, 02912, United States
Thomas J Webster
Affiliation:
[email protected], Brown University, Divsion of Engineering, 182 Hope Street, Providence, RI, 02912, United States
Get access

Abstract

The potential of nanocrystalline diamond films (NDFs) for biological applications has been addressed by a variety of recent researchers. In the present work, we consider the topographical evolution of NDFs fabricated by microwave plasma assisted chemical-vapor-deposition (MPCVD) and its influence on osteoblast (bone forming cells) functions. One group of NDFs formed in this study were grown with 0.67% methane, 5%∼20% hydrogen and argon. The other group of NDFs composed of nano diamond and amorphous carbon was created with indirect exposure to plasma with 0.67% methane, 20% hydrogen and argon. Scanning electron microscope (SEM) images revealed that the nano diamond grains in the first group of NDFs evolved from round shapes into faceted and successively cubic shapes as hydrogen increased, whereas the second group of NDFs consisted of nano platelet grains. Atomic force microscopy (AFM) analysis confirmed this evolution as well as the variation of surface roughness. Cell results demonstrated that osteoblast adhesion and proliferation on NDFs varied dramatically depending on the different topographical features of the films. Specifically, results showed that NDFs with grain size less than 100 nm could be coated on the stem of a hip implant to promote cell adhesion. In contrast, NDFs with grain size greater than 200 nm or NDF with nano platelet grains may be optimal for the inside of acetabular articulation where cell adhesion is not preferred but wear-resistance is important. Further observation by contact angle measurement suggested that the differences in cellular adhesion and proliferation were related to the wettability associated to the topographical features of NDFs surfaces.

Keywords

diamondthin filmbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1039: Symposium P – Diamond Electronics–Fundamentals to Applications II , 2007 , 1039-P03-02
Copyright
Copyright © Materials Research Society 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. O'Hera, M.E., Clausing, C.J., Oliver, W.C., Parrish, R.H., Mater Res Soc Extended Abstr, EA–19(1989) pp.131–137.Google Scholar
2. Hayward, I.P. and Singer, I.L. in Proc 2nd Int Conf New Diamond Sci Technol., edited by Messier, R., Glass, J.T., Bulter, J.E., Roy, R., (Materials Research Society, Pittsburgh, PA, 1986) pp.785–789.Google Scholar
3. Lappalainen, R., J.Biomed.Mater.Res. 66B, 410–413 (2003).Google Scholar
4. Spear, K.E., J. Am Ceram Soc. 72, 171–191 (1989).Google Scholar
5. Drory, M.D., Gardinier, C.F. and Speck, J.S., J Am Ceram Soc. 74, 3148–3150 (1991).Google Scholar
6. Tang, L., Tsai, C. and Gerberich, W.W., Biomaterials 16, 483–488 (1995).Google Scholar
7. Popov, C., Kulisch, W. and Reithmaier, J.P., Diamond and Related Materials 16, 735–739 (2007).Google Scholar
8. Garguilo, J.M., Davis, B.A. and Buddie, M., Diamond and Related Materials 13, 595–599 (2004).Google Scholar
9. Zhou, D., Gruen, D.M. and Qin, L.C., J Appl. Phys. 84, 1981–1989 (1998).Google Scholar
10. Neinhuis, C. and Barthlott, W., New Phytol. 138, 91–98 (1998).10.1046/j.1469-8137.1998.00882.xGoogle Scholar
11. Wilson, C.J., Clegg, R.E. and Leavesley, D.I., Tissue Engineering 11, 1–18 (2005).Google Scholar