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Tailoring Magnetic Microspheres with Controlled Porosity

Published online by Cambridge University Press:  26 February 2011

Muhammet S Toprak ,
Brandon J McKenna ,
Herb Waite  and
Galen D Stucky
Muhammet S Toprak
Affiliation:
[email protected], University of California, Dept of Chemistry, Dept of Chemistry and Biochemistry, Santa Barbara CA 93106, Santa Barbara, CA, 93117, United States, +1 805 8937759
Brandon J McKenna
Affiliation:
[email protected], UC, Chemistry and Biochemistry, Santa Barbara, CA, 93117, United States
Herb Waite
Affiliation:
[email protected], UC, Chemistry and Biochemistry, Santa Barbara, CA, 93117, United States
Galen D Stucky
Affiliation:
[email protected], UC, Chemistry and Biochemistry, Santa Barbara, CA, 93117, United States
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Abstract

The synthesis of organic and inorganic nano- and microspheres has attracted much interest for a variety of applications ranging from drug delivery to chemical storage and catalysis. We recently demonstrated the assembly of magnetic nanoparticles and polycations into hybrid microspheres in a single-step synthesis via complex coacervation. These microspheres showed viability for bio-applications as indicated by toxicity tests, and are therefore potential targeted drug delivery devices, as they can be directed magnetically. This work reports the recent progress on the potential use of these assemblies in drug release by controlling their porosity. Fluorescein tagged dextran molecules with different MW have been infiltrated into these entities to determine critical pore size by confocal fluorescence microscopy. Different physicochemical characterization results are also presented.

Keywords

nanostructuremagneticcombinatorial synthesis
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 969: Symposium W – Heterogeneous Integration of Materials for Passive Components and Smart Systems , 2006 , 0969-W03-11
Copyright
Copyright © Materials Research Society 2007

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