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Synthesis of Hydroxyapatite – Hyaluronic acid Nano Composite Sol under Well-Controlled Condition

Published online by Cambridge University Press:  01 February 2011

Yuko Ishikawa  and
Mamoru Senna
Yuko Ishikawa
Affiliation:
Faculty of Science and Technology, Keio University, 3–14–1 Hiyoshi, Yokohama 223–8522, Japan
Mamoru Senna
Affiliation:
Faculty of Science and Technology, Keio University, 3–14–1 Hiyoshi, Yokohama 223–8522, Japan
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Abstract

Hydroxyapatite (HAp) – Hyaluronic acid (HYA) nano composite sol was prepared at room temperature, at pH 8, by a coprecipitation method from CaCl2 or Ca(CH3COO)2 and H3PO4. These soluble Ca sources were used in order to increase the number of nucleation sites for HAp on HYA. Starting materials were supplied by two kinds of processes to give solution(s) of only PO43- or, PO43- and Ca2+ simultaneously into HYA solution containing Ca2+. Morphology of the aggregates and crystallite size as well as lattice parameters of the HAp were examined by TEM and XRD data with Rietveld refinement. We observed needle like aggregates of crystallites of HAp. Supplying methods of Ca sources controlled the aspect ratio of the aggregates and HAp crystallite. Lattice parameters of the samples prepared from CaCl2 shifted towards those of chloroapatite. Those from Ca(CH3COO)2, however, correspond to the literature values of single crystal HAp. The results of FT-IR spectra and the changes of rheological property indicate the electrostatic interactions between negatively charged functional groups of HYA and HAp.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 788: Symposium L – Continuous Nanophase and Nanostructured Materials , 2003 , L3.21
Copyright
Copyright © Materials Research Society 2004

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References

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