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Studies on the Interaction of Water-Soluble Fullerols with BSA and the Effects of Metallic Ions

Published online by Cambridge University Press:  21 March 2011

Xu Bingshe ,
Liu Xuguang ,
Yan Xiaoqin ,
Qiao Jinli  and
Jin Weijun
Xu Bingshe
Affiliation:
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China, 030024
Liu Xuguang
Affiliation:
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China, 030024
Yan Xiaoqin
Affiliation:
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China, 030024
Qiao Jinli
Affiliation:
College of Science, Taiyuan University of Technology, Taiyuan, Shanxi, China, 030024
Jin Weijun
Affiliation:
Department of Chemistry, Shanxi University, Taiyuan, Shanxi, China, 030006
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Abstract

The interaction of water-soluble C60 derived fullerols with bovine serum albumin (BSA) in physiological environment was studied in detail by the fluorescence method. Experiments showed that the interaction of fullerols with BAS is mainly in the manner of non-covalent hydrogen bond. Based on the measurements of fluorescence intensity, the apparent binding constant K and the binding site number n were obtained with K=4000 and n=1, and the energy transfer efficiency in the reaction is 0.63. Besides, the effects of metallic ions such as Cu2+, Fe3+ and Cr(VI) on the interaction of fullerols with BSA were investigated. It was found that the effects of the metallic ions are quite different from each other. Low concentrations of Cu2+ can promote the interactions between fullerols and BSA, while high concentrations of Fe3+ or Cr(VI) favorite the interactions between fullerols and BSA.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 675: Symposium W – Nanotubes, Fullerenes, Nanostructured and Disordered Carbon , 2001 , W7.4.1
Copyright
Copyright © Materials Research Society 2001

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References

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