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Stable Nanocapsules Formed from Headgroup Polymerization of Natural Phospholipids

Published online by Cambridge University Press:  10 February 2011

Glenn E. Lawson  and
Alok Singh
Glenn E. Lawson
Affiliation:
Center for Bio/Molecular Science and Engineering, Naval Research Laboratory 4555 Overlook Ave. Washington, DC 20375
Alok Singh
Affiliation:
Center for Bio/Molecular Science and Engineering, Naval Research Laboratory 4555 Overlook Ave. Washington, DC 20375
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Abstract

Formation of lipid based hollow, spherical nanocapsules is reported. N-acylphosphotidylethanolamine (egg) derivatives equipped with divinylbenzoyl functionality in their headgroup region were synthesized to explore their polymerization behavior in vesicles. Polymerizable phospholipids alone produced vesicles as an aqueous dispersion and produced stable nanocapsules upon polymerization at room temperature. These structures survived a redispersed cycle following lyophilization and maintained their structural integrity in non-aqueous solvent.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 775: Symposium P – Self-Assembled Nanostructured Materials , 2003 , P5.5
Copyright
Copyright © Materials Research Society 2003

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References

1. Bangham, A. D. Adv. Lipid Res. 1963, 1, 65–104.Google Scholar
2. Juliano, R. L. in Liposomes: from physical properties to therapeutic applications, Knight, C. G. ed., Elsevier/North Holland Publishers, New York, 1981, Chapter 14, pp. 391–407.Google Scholar
3. Mayhew, E.; Papahadjopoulos, D. Liposomes;, M. J. Ostro, Ed., MarcelDekker:New York, 1983, Chapter 7, pp. 289–341.Google Scholar
4. Regen, S. L.; Czech, B.; Singh, A. J. Am. Chem. Soc. 1980, 102, 6638–6640.Google Scholar
5. Hub, H.; Hupfer, B.; Koch, H.; Ringsdorf, H. Angew. Chem. Int. Ed. Engl. 1980, 19, 938–940.Google Scholar
6. Johnston, D. S.; Sanghera, S.; Pons, M.; Chapman, D. Biochim. Biophys. Acta 1980, 602, 57–69.Google Scholar
7. O'Brien, D. F.; Klingbiel, R. T.; Whitesides, T. H. J. Polym. Sci. Polym. Lett. Ed., 1981, 19, 85–101.Google Scholar
8. Lawson, G. E.; Breen, J. J.; Marquez, M.; Singh, A.; Smith, B.D. Langmuir 2003, 19, 3557–3560.Google Scholar
9. Lawson, G. E.; Lee, Y.; Singh, A. Langmuir, 2003 (in review process).Google Scholar
10. Liu, S.; O'Brien, D. F. J. Am. Chem. Soc. 2002, 124, 6037–6042.Google Scholar