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Sol-gel Encapsulated Gold-Silica Nanoshell-based SERS Sensors

Published online by Cambridge University Press:  01 February 2011

Yu-Jen Lin ,
Pankti Gala  and
Sandra Whaley Bishnoi
Yu-Jen Lin
Affiliation:
Illinois Institute of Technology, BCPS, 3101 S. Dearborn, LS 182, Chicago, IL, 60616, United States, 312-567-8922
Pankti Gala
Affiliation:
[email protected], Illinois Institute of Technology, Biomedical Engineering, Chicago, IL, 60616, United States
Sandra Whaley Bishnoi
Affiliation:
[email protected], Illinois Institute of Technology, BCPS, 3101 S. Dearborn St. LS 182, Chicago, IL, 60616, United States
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Abstract

We have used sol-gel methods to immobilize gold-silica nanoshells to create robust SERS based sensors. Using a protocol commonly used to immobilize proteins, biologically friendly SERS sensors for the study of gold binding peptides and proteins have been created. Specifically, by combining tetramethyl orthosilicate (TMOS), methyltrimethoxysilicate (MTMS), phosphate buffer, and gold nanoparticles we have created sol-gels with reduced fluorescence and Raman backgrounds. The resulting substrates have been tested using the Raman scattering response of 4-mercaptonbenzoic acid (4-MBA) to determine porosity and long-term stability of this SERS substrate. Multiple rinse cycles using phosphate buffer showed no significant decline in the SERS response of the substrate up to ten rinse cycles. Future studies will test the feasibility of using such substrates for the detection of biomolecules on the surface of gold.

Keywords

Raman spectroscopysol-gelnanoscale
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1063: Symposium OO – Solids at the Biological Interface , 2007 , 1063-OO03-05
Copyright
Copyright © Materials Research Society 2008

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References

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