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Single Stranded dna Translocation Through a Fluctuating Nanopore

Published online by Cambridge University Press:  01 February 2011

O. Flomenbom  and
J. Klafter
O. Flomenbom
Affiliation:
School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel
J. Klafter
Affiliation:
School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel
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Abstract

We investigate the translocation of a single stranded DNA (ssDNA) through a pore, which fluctuates between two conformations, by using coupled master equations (ME). The probability density function (PDF) of the first passage times (FPT) of the translocation process is calculated, displaying a triple, double or mono-peaked behavior, depending on the system parameters. An analytical expression for the mean first passage time (MFPT) of the translocation process is derived, and provides an extensive characterization of the translocation process.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 790: Symposium P – Dynamics in Small Confining Systems–2003 , 2003 , P7.4
Copyright
Copyright © Materials Research Society 2004

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References

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