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Role of Plasma Proteins in Corrosion of 316L Stainless Steel In Vitro

Published online by Cambridge University Press:  22 February 2011

J. L. Bence ,
J. Black  and
S. N. Mitchell
J. L. Bence
Affiliation:
McKay Laboratory of Orthopaedic Surgery Research, Department of Orthopaedic Surgery and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104
J. Black
Affiliation:
McKay Laboratory of Orthopaedic Surgery Research, Department of Orthopaedic Surgery and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104
S. N. Mitchell
Affiliation:
McKay Laboratory of Orthopaedic Surgery Research, Department of Orthopaedic Surgery and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104
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Abstract

Plasma proteins have been recognized as playing a role in the corrosion of metals used as medical implants. In this study, we examined the early events of anodic corrosion of 316L stainless steel in saline/plasma mixtures. Polished, annealed, cleaned and passivated 316L electrodes with a surface area/body fluid volume (SA/BFV) ratio of 23X were driven anodically in a 100 ml acid cleaned cell at 950 and 1150 mV (vs. SCE). Electrolyte solutions of isotonic saline (pH = 7.4) containing 0, 5, 10 and 25 volume percent human plasma were used. Aliquots of solution were taken at intervals and analyzed for Cr, Ni and Fe by atomic absorption spectrophotometry. Corrosion continued until a total charge of 1.0 to 1.5 C was passed. Plots of solution metal concentration versus electrolyte solution composition, calculated at an isocoulombic point (Q = 0.5 C) and adjusted for initial concentration, were prepared to test for effects of the presence of plasma proteins. Increases in elemental release rates of up to 3x (p 0.05) were found, with peak effects in 5 and 10 volume percent plasma solutions. The effects depend upon anodic potential, metal species, plasma protein concentration and possibly plasma composition.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 55: Symposium G – Biomedical Materials , 1985 , 387
Copyright
Copyright © Materials Research Society 1986

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References

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