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Rheology and Biocompatibility of Poly(lactide)-poly(ethylene oxide)-poly(lactide) Hydrogels

Published online by Cambridge University Press:  01 February 2011

Sarvesh K. Agrawal ,
Kyuong S. Chin ,
Naomi Sanabria-Delong ,
Khaled A. Aamer ,
Heidi Sardinha ,
Gregory N. Tew ,
Susan C. Roberts  and
Surita R. Bhatia
Sarvesh K. Agrawal
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts Amherst 120. Governors Drive, Amherst, MA 01003, U.S.A.
Kyuong S. Chin
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts Amherst 120. Governors Drive, Amherst, MA 01003, U.S.A.
Naomi Sanabria-Delong
Affiliation:
2Department of Chemical Engineering, University of Massachusetts Amherst 686, North Pleasant Street, Amherst, MA 01003, U.S.A.
Khaled A. Aamer
Affiliation:
2Department of Chemical Engineering, University of Massachusetts Amherst 686, North Pleasant Street, Amherst, MA 01003, U.S.A.
Heidi Sardinha
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts Amherst 120. Governors Drive, Amherst, MA 01003, U.S.A.
Gregory N. Tew
Affiliation:
2Department of Chemical Engineering, University of Massachusetts Amherst 686, North Pleasant Street, Amherst, MA 01003, U.S.A.
Susan C. Roberts
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts Amherst 120. Governors Drive, Amherst, MA 01003, U.S.A.
Surita R. Bhatia
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts Amherst 120. Governors Drive, Amherst, MA 01003, U.S.A.
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Abstract

We report rheological data on hydrogels formed from triblock copolymers of poly(L-lactide) (PLLA) and poly(ethylene oxide) (PEO). We are able to create gels with elastic moduli greater than 10,000 Pa, which is an order of magnitude higher than previously achieved with related physically associated gels of similar chemistry. Moreover, the value of the elastic modulus strongly depends on PLLA block length, offering a mechanism to control the mechanical properties as desired for particular applications. Additionally, we have developed protocols for using these materials for cell encapsulation and present preliminary cell viability studies for encapsulated human liver cells (HepG2 cell line). Our results have implications for the design of new materials for soft tissue engineering, where native tissues have moduli in the kPa range.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 844: Symposium Y – Mechanical Properties of Bio-Inspired and Biological Materials , 2004 , y9.8
Copyright
Copyright © Materials Research Society 2005

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References

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