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Poly(Methacrylic Acid-g-Ethylene Glycol) Hydrogels as pH Responsive Biomedical Materials

Published online by Cambridge University Press:  15 February 2011

Cristi L. Bell  and
Nicholas A. Peppas
Cristi L. Bell
Affiliation:
School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283
Nicholas A. Peppas
Affiliation:
School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283
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Abstract

Novel graft copolymeric, pH responsive hydrogels have been synthesized by solution polymerization. Poly(methacrylic acid-g-ethylene glycol) hydrogels exhibit reversible complexation as a function of pH because of hydrogen bonding between the PEG grafts and the PMAA main chains. These gels are being developed as pH responsive membranes for use in biomedical applications. ATR-FTIR results indicate that there is hydrogen bonding occurring in membranes swollen under conditions favorable for complexation. Equilibrium swelling studies have shown that the pH of the surrounding environment has a significant effect on the swelling behavior of these membranes. The swelling behavior has also been shown to respond rapidly to changing pH conditions. P(MAA-g-EG) membranes also show pH sensitive permeability toward solutes as a result of this environmentally sensitive swelling.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 199
Copyright
Copyright © Materials Research Society 1994

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