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Patterning of Cells on Bioresist for Tissue Engineering Applications

Published online by Cambridge University Press:  01 February 2011

Yusif Umar ,
Muthiah Thiyagarajan ,
Craig Halberstadt  and
K. E. Gonsalves
Yusif Umar
Affiliation:
Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223
Muthiah Thiyagarajan
Affiliation:
Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223
Craig Halberstadt
Affiliation:
Department of General Surgery Research, Carolinas Medical Center, Charlotte, NC 28232
K. E. Gonsalves*
Affiliation:
Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223
*
* Corresponding author: email address: [email protected] (K.E. Gonsalves)
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Extract

Engineering functional tissues and organs successfully depends on the ability to control cell orientation and distribution. Materials used for such purposes therefore have to be designed to facilitate cell distribution and eventually guide tissue regeneration in 3D.The field of tissue engineering hinges on developing degradable polymeric scaffolds that promote cell proliferation and expression of desired physiological behaviors through careful control of the polymer surface.

The development of materials for tissue engineering and guided tissue regeneration has accelerated over the last decade.[1] It has been demonstrated that non-patterned cells are effectively not tissue. “Tissues require that cells be placed and hold precise places often with precise orientations” [2–3]. Cell patterning is therefore very important for tissue engineering. We have developed a biocompatible, biostable chemically amplified bioresist, with which patterns are generated without involving harsh chemical treatment.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA5.29
Copyright
Copyright © Materials Research Society 2005

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References

REFERENCES

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