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Osteogenic Cell Attachment to Degradable Polymers

Published online by Cambridge University Press:  15 February 2011

Kevin E. Healy ,
Davis Tsai  and
Jung E. Kim
Kevin E. Healy
Affiliation:
Depts. of Biological Materials and Biomedical Engineering, Northwestern University, Chicago, IL.
Davis Tsai
Affiliation:
School of Medicine, Northwestern University, Chicago, IL.
Jung E. Kim
Affiliation:
Dept. of Materials Science and Engineering, Northwestern University, Evanston, IL.
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Abstract

Modifications were made to increase osteogenic cell adhesion to homo and copolymers of lactic and glycolic acid. A synthetic peptide containing the cell attachment signal Arginine-Glycine-Aspartate (RGD) was loaded into the polymers or adsorbed to the polymers' surfaces. Cell attachment was assayed after 24 hours incubation with an osteogenic cell line (ROS 17/2.8). Statistically significant differences in cell adhesion occurred between the polymers with the adsorbed peptides and the other treatment groups. Significant differences were not observed for the peptide loaded polymers and controls. These data indicate that precoating the polymer surface with a RGD-containing peptide prior to exposure to osteogenic cells increased cell attachment. For the current materials tested, the surface modification is preferred to increase osteogenic cell adhesion to degradable polyesters.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 109
Copyright
Copyright © Materials Research Society 1992

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References

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