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Optical Manipulation of Objects in Microfluidic Devices

Published online by Cambridge University Press:  01 February 2011

Erhan Ata ,
Aaron L. Birkbeck ,
Mihrimah Ozkan ,
Cengiz S. Ozkan ,
Richard Flynn ,
Mark Wang  and
Sadik Esener
Erhan Ata
Affiliation:
Electrical Engineering Department, University of California, San Diego
Aaron L. Birkbeck
Affiliation:
Electrical Engineering Department, University of California, San Diego
Mihrimah Ozkan
Affiliation:
Electrical Engineering Department, University of California, Riverside
Cengiz S. Ozkan
Affiliation:
Mechanical Engineering Department, University of California, Riverside
Richard Flynn
Affiliation:
Electrical Engineering Department, University of California, San Diego
Mark Wang
Affiliation:
Electrical Engineering Department, University of California, San Diego
Sadik Esener
Affiliation:
Electrical Engineering Department, University of California, San Diego
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Abstract

In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an “optical handle”. Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 729: Symposium U – MEMS and BioMEMS , 2002 , U1.6
Copyright
Copyright © Materials Research Society 2002

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