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Near Total Blood Exchange with Perfluorochemical Preparations

Published online by Cambridge University Press:  26 February 2011

Robert P. Geyer ,
Kenneth Taylor ,
Robert Eccles ,
Therese Zerbonne ,
Anna Gallagher ,
Thomas Goodin  and
Steven Williams
Robert P. Geyer
Affiliation:
Harvard School of Public Health, Dept. of Nutrition, 665 Huntington Ave., Boston, MA 02115
Kenneth Taylor
Affiliation:
Harvard School of Public Health, Dept. of Nutrition, 665 Huntington Ave., Boston, MA 02115
Robert Eccles
Affiliation:
Harvard School of Public Health, Dept. of Nutrition, 665 Huntington Ave., Boston, MA 02115
Therese Zerbonne
Affiliation:
Harvard School of Public Health, Dept. of Nutrition, 665 Huntington Ave., Boston, MA 02115
Anna Gallagher
Affiliation:
Harvard School of Public Health, Dept. of Nutrition, 665 Huntington Ave., Boston, MA 02115
Thomas Goodin
Affiliation:
Harvard School of Public Health, Dept. of Nutrition, 665 Huntington Ave., Boston, MA 02115
Steven Williams
Affiliation:
Harvard School of Public Health, Dept. of Nutrition, 665 Huntington Ave., Boston, MA 02115
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Abstract

Near total blood replacement in rats has been accomplished with perfluorochemical (PFC) preparations containing hydroxyethylstarch and electrolytes. F-dimethyladamantane (F-DMA) was used alone or mixed with F-N,N-dimethylcyclohexylmethylamine (F-CHA). These compounds were emulsified to yield particles approximately 150 to 250 nanometers in diameter. The nonionic surfactant, Pluronic F68, was used as the emulsifying agent. Over ninety percent of the rats survived when their hematocrits were taken to 3 volume percent or lower from a pre-perfusion value of about 44 volume percent. In spite of the reduction in total mixed venous oxygen concentration, the oxygen partial pressure rose. During the perfusion the rats breathed 100 percent oxygen, but during the subsequent period this was decreased 10 percent per day. Six to 7 days later the hematocrits had risen to 30 to 40 volume percent. Thereafter the animals continued to develop and grow.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 159
Copyright
Copyright © Materials Research Society 1988

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