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Macromolecular Nutriend Limitations of Encapsulated Cells
Published online by Cambridge University Press: 15 February 2011
Abstract
Encapsulated cells are likely to encounter transport limitations of trace nutrients carried by macromolecules due to a high diffusion resistance in the encapsulating membrane. We modeled the transport of transferrin to encapsulated cells and found that the transport limitation of transferrin is potentially significant in comparison to oxygen, which is limiting in unencapsulated tissue. Since transferrin is the primary biological iron carrier, deprivation of transferrin to encapsulated cells may limit long term function and viability in vivo.
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- Copyright © Materials Research Society 1994
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