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In-Vivo Degradation of a Poly(Propylene-Fumarate) Biodegradable, Particulate Composite Bone Cement

Published online by Cambridge University Press:  21 February 2011

Daveed D. Frazier ,
Vijay K. Lathi ,
Tobin N. Gerhart ,
David E. Altobelli  and
Wilson C. Hayes
Daveed D. Frazier
Affiliation:
Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Charles A. Dana Research Institute, Harvard Thorndike Laboratory, Beth Israel Hospital and Harvard Medical School, 330 Brookline Avenue, RN115, Boston, Massachusetts 02215
Vijay K. Lathi
Affiliation:
Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Charles A. Dana Research Institute, Harvard Thorndike Laboratory, Beth Israel Hospital and Harvard Medical School, 330 Brookline Avenue, RN115, Boston, Massachusetts 02215
Tobin N. Gerhart
Affiliation:
Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Charles A. Dana Research Institute, Harvard Thorndike Laboratory, Beth Israel Hospital and Harvard Medical School, 330 Brookline Avenue, RN115, Boston, Massachusetts 02215
David E. Altobelli
Affiliation:
Department of Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02215
Wilson C. Hayes
Affiliation:
Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Charles A. Dana Research Institute, Harvard Thorndike Laboratory, Beth Israel Hospital and Harvard Medical School, 330 Brookline Avenue, RN115, Boston, Massachusetts 02215
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Abstract

We have developed a biodegradable particulate composite bone cement consisting of a poly(propylene glycol-fumarate)-(methylmethacrylate) matrix mixed with calcium carbonate and tricalcium phosphate particulates. Previous ex-vivo studies suggest that this system provides sufficient strength for a number of potential clinical applications including structural reinforcement of osseous defects, supplementation of internal fixation of age-related fractures, and delivery of antibiotics to treat osteomyelitis. Ex-vivo degradation assays have also shown that the cement approximates physiologic conditions of bone remodeling as it degrades. In order to evaluate the in-vivo responses to this material, we implanted cement specimens subcutaneously in rats for up to 84 days. Compressive strength of the subcutaneous implants increased linearly through day 21 to 4.91 MPa, then decreased linearly by day 84 to less than 1 MPa. We conclude that this PPFMMA system is biocompatible and biodegradable, and has the potential for use as an orthopedic bone cement. Future studies will be directed toward characterizing the intraosseous histological response and at coordinating the rate of cement degradation with bony ingrowth.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 394: Symposium Z – Polymers in Medicine and Pharmacy , 1995 , 15
Copyright
Copyright © Materials Research Society 1995

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References

1. Cohn, D. and Younes, H., J. Biomed. Mat. Res. 22,993 (1988)Google Scholar
2. Constantz, B.R., Ison, I., Fulmer, M.T., Poser, R.D., Smith, S.T., VanWagoner, M., Ross, J., Goldstein, S.A., Jupiter, J.B. and Rosenthal, D.I., Science 267, 1796 (1995)Google Scholar
3. Ducheyne, P., Hench, L.L., Kagan, A., Martens, M., Bursens, A. and Mulier, J.C., J. Biomed. Mat. Res. 14, 225 (1980)Google Scholar
4. Frazier, D.D., Lathi, V.K., Gerhart, T.N. and Hayes, W.C., J. Biomed. Mat. Res. submitted (1995)Google Scholar
5. Gerhart, T.N., Hayes, W.C. and Stern, S.H., J. Orthop. Res. 4, 76 (1986)Google Scholar
6. Gerhart, T.N., Roux, R.D., Horowitz, G., Miller, R.L., Hanff, P. and Hayes, W.C., J. Orthop. Res. 6, 585 (1988)Google Scholar
7. Higshi, S., Yamamuro, T., Nakamura, T., Ikada, Y, Hyon, S.H. and Jamshidi, K., Biomaterials 7, 183 (1986)Google Scholar
8. Hollinger, J.O., J. Biomed. Mat. Res. 17, 71 (1983)Google Scholar
9. Hollinger, J.O. and Battistone, G.C., Clin. Orthop. 207, 290 (1986)Google Scholar
10. Ibay, A.C., Whalley, C.E., Miller, R.A., Carr, H. and Battistone, G.C., in US Army Institute of Dental Research, Walter Reed Army Medical Ctr. (1993)Google Scholar
11. Kleeman, B.C., Gerhart, T.N. and Hayes, W.C., in Proc. Am. Soc. for Biomaterials (1987)Google Scholar
12. Saha, S. and Pal, S., J. Biomed. Mat. Res. 18, 435 (1984)Google Scholar
13. Topoleski, L.T.D., Ducheyne, P. and Cuckler, J.M., J. Biomed. Mat. Res. 24, 135 (1990)Google Scholar
14. Uchida, A., Araki, N., Shinto, Y., Yoshikawa, H., Kurisaki, E. and Ono, K., J. Bone Joint Surg. [Br] 72, 298 (1990)Google Scholar
15. Wilson, J. and Merwin, G., J. Biomat. Res. 22, 159 (1988)Google Scholar