Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-27T02:42:38.320Z Has data issue: false hasContentIssue false
  • English
  • Français

Investigation of Nanophysical Properties of Aging Polyamide Nanofibrillar Tissue Scaffolds by TEM, SAED, Contact Angle and Raman Spectroscopies

Published online by Cambridge University Press:  23 April 2012

Virginia M. Ayres ,
Kan Xie ,
Volkan Mujdat Tiryaki ,
Ijaz Ahmed  and
David I. Shreiber
Virginia M. Ayres
Affiliation:
Electrical and Computer Engineering, Michigan State University, East Lansing, MI, United States.
Kan Xie
Affiliation:
Electrical and Computer Engineering, Michigan State University, East Lansing, MI, United States.
Volkan Mujdat Tiryaki
Affiliation:
Electrical and Computer Engineering, Michigan State University, East Lansing, MI, United States.
Ijaz Ahmed
Affiliation:
Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
David I. Shreiber
Affiliation:
Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Get access

Abstract

The nanoscale physical properties of newly electrospun polyamide nanofibrillar matrices < 1 year old versus those that were > 3 year old were investigated with transmission electron microscopy, selected area electron diffraction, contact angle measurements, and Raman spectroscopy. Significant differences in crystallinity, hydrophobicity, and chemistry were found and correspondingly different cell responses by cerebellar granular neurons were observed. The properties of the aged nanofibrillar scaffolds evoked a response for neuron burrowing into a more 3-dimensional environment in addition to better facilitation of neurite outgrowth. The nanophysical properties of tissue scaffolds have been recently shown to directly and indirectly regulate cellular responses. As physical properties can evolve over time, the present investigation addresses the issue of tissue scaffold shelf life, with possible changes in directive signals to cells.

Keywords

nanostructurecrystallinebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1417: Symposium KK – Biomaterials for Tissue Regeneration , 2012 , mrsf11-1417-kk06-31
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

[1] Meiners, S., Ahmed, I., Ponery, A.S., Amor, N., Ayres, V.M., Fan, Y., Chen, Q. and Babu, A.N., Polymer Int. 56, 1340 (2007).Google Scholar
[2] Delgado-Rivera, R., Harris, S.L., Ahmed, I., Babu, A.N., Patel, R., Ayres, V.M., Flowers, D.A., and Meiners, S., Matrix Bio. 28, 137 (2009).Google Scholar
[3] Roggendorf, E., J. Biomed. Mater. Res. 10, 123 (1976).Google Scholar
[4] Hatamleh, M.M., Polyzois, G.L., Silikas, N. and Watts, D.C., J. Prosthodont. 20, 439 (2011).Google Scholar
[5] Tiryaki, V.M., Ayres, V.M., Khan, A., Delgado-Rivera, R., Ahmed, I., Meiners, S., in Polymer Nanofibers-Fundamental Studies and Emerging Applications, edited by Tanioka, A. (Mater. Res. Soc. Symp. Proc. 1240E, Warrendale, PA, 2010), 1240-WW09-13.Google Scholar
[6] Fan, Y., Chen, Q., Ayres, V.M., Baczewski, A.D., Udpa, L. and Kumar, S., Int. J. Nanomed. 2, 651 (2007).Google Scholar
[7] Ferrari, A.C. and Robertson, J., Phys. Rev. B 64, 075414 (2001).Google Scholar
[8] Georges, P.C., Miller, W.J., Meaney, D.F., Sawyer, E.S. and Janmey, P.A., Biophys. J. 90, 3012 (2006).Google Scholar