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In Vitro Examination of Poly(glycerol sebacate) Degradation Kinetics: Effects of Porosity and Cure Temperature

Published online by Cambridge University Press:  04 February 2014

Nadia M. Krook ,
Courtney LeBlon  and
Sabrina S. Jedlicka
Nadia M. Krook
Affiliation:
Lehigh University Center for Advanced Materials & Nanotechnology, Bethlehem, PA, 18015, U.S.A
Courtney LeBlon
Affiliation:
Materials Science & Engineering, Center for Advanced Materials & Nanotechnology, Bethlehem, PA, 18015, U.S.A
Sabrina S. Jedlicka
Affiliation:
Lehigh University Center for Advanced Materials & Nanotechnology, Bethlehem, PA, 18015, U.S.A Mechanical Engineering & Mechanics, Center for Advanced Materials & Nanotechnology, Bethlehem, PA, 18015, U.S.A Bioengineering Program, Center for Advanced Materials & Nanotechnology, Bethlehem, PA, 18015, U.S.A
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Abstract

Poly(glycerol sebacate) (PGS) is a biodegradable and biocompatible elastomer that has been used in a wide range of biomedical applications. While a porous format is common for tissue engineering scaffolds, to allow cell ingrowth, PGS degradation has been primarily studied in a nonporous format. The purpose of this research was to investigate the degradation of porous PGS at three frequently used cure temperatures: 120°C, 140°C, and 165°C. The thermal, chemical, mechanical, and morphological changes were examined using thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, compression testing, and scanning electron microscopy. Over the course of the 16-week degradation study, the samples’ pores collapsed. The specimens cured at 120°C demonstrated the most degradation and became gel-like after 16 weeks. Thermal changes were most evident in the 120°C and 140°C cure PGS specimens, as shifts in the melting and recrystallization temperatures occurred. Porous samples cured at all three temperatures displayed a decrease in compressive modulus after 16 weeks. This in vitro study helped to elucidate the effects of porosity and cure temperature on the biodegradation of PGS and will be valuable for the design of future PGS scaffolds.

Keywords

biomaterialpolymerscanning electron microscopy (SEM)
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1621: Symposium H/C/D/J – Advances in Structures, Properties and Applications of Biological and Bioinspired Materials , 2014 , pp. 87 - 92
Copyright
Copyright © Materials Research Society 2014 

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